Optical Coherence Tomography Angiography Compared with Indocyanine Green Angiography in Central Serous Chorioretinopathy
Optical Coherence Tomography Angiography Compared with Indocyanine Green Angiography in Central Serous Chorioretinopathy
复制标题
光学相干断层扫描血管造影与吲哚菁绿血管造影在中心性浆液性脉络膜视网膜病变中的比较
DOI：
10.1038/s41598-019-42623-x
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发表时间：
2019-04-16
影响因子：
4.6
通讯作者：
Zhao, Mingwei
中科院分区：
文献类型：
--
作者：
Hu, Jie;Qu, Jinfeng;Zhao, Mingwei
本文的目的是比较中心性浆液性脉络膜视网膜病变（CSC）患者的光学相干断层扫描血管造影（OCTA）和吲哚菁绿色血管造影（ICGA）。收集所有入选患者的OCTA、ICGA和荧光素血管造影（FA）图像并进行比较。对面脉络膜毛细血管OCTA和ICGA图像上的异常区域进行标注并进行比较。脉络膜毛细血管OCTA异常主要有三种类型：A型，粗颗粒状高反射区61眼（92.4%）; B型，A型周围圆形暗晕54眼（81.8%）;有54只眼（81.8%）表现出所有三种类型的异常，7只眼（10.6%）仅表现出A型和C型异常，5只眼（7.6%）仅表现出C型异常。对于1级和2级，OCTA上A型的平均JI和ICGA上的高荧光面积分别为0.84 +/- 0.15和0.82 +/- 0.23。OCTA上的A型面积在统计学上大于ICGA上的高荧光面积（P = 0.01 [配对t检验]）。总之，在CSC的OCTA图像上发现异常。大部分眼OCTA的粗颗粒高反射区与ICGA的高通透性区相对应。
The purpose of this article is to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC). OCTA, ICGA and fluorescein angiography (FA) images of all enrolled patients were collected and compared. Abnormal areas were annotated on en face choriocapillaris OCTA and ICGA images and compared with each other. We found three main types of anomalies in choriocapillaris OCTA images: type A, coarse granulated high reflective area (61 eyes [92.4%]); type B, roundish dark halo around Type A (54 eyes [81.8%]); and type C, coarse granulated low reflective area (66 eyes [100%]). There were 54 eyes (81.8%) that exhibited all three types abnormalities, 7 (10.6%) had only type A and C abnormalities, and 5 (7.6%) had only type C abnormalities. The Mean JI of type A on OCTA and hyperfluorescence area on ICGA was 0.84 +/- 0.15 and 0.82 +/- 0.23 for grader 1 and 2, respectively. Type A area on OCTA had a statistically larger area than hyperfluorescence on ICGA (P = 0.01 [paired t-test]). In summary, abnormalities were found on OCTA images of CSC. Coarse granulated high reflective area in OCTA corresponded well with the hyper-permeability area in ICGA in most of the eyes.