Electrophysiological measures of resting state functional connectivity and their relationship with working memory capacity in childhood.
Electrophysiological measures of resting state functional connectivity and their relationship with working memory capacity in childhood.
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DOI：
10.1111/desc.12297
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发表时间：
2016-01
影响因子：
3.7
通讯作者：
Astle DE
中科院分区：
文献类型：
--
作者：
Barnes JJ;Woolrich MW;Baker K;Colclough GL;Astle DE
功能连接是不同大脑区域的神经元活动时间过程的统计关联，支持特定的认知过程。这种活动的协调可能对认知的复杂方面非常重要，例如从高阶控制区域到低阶功能特定区域的波动任务目标的通信。这些功能连接中的一些是可识别的，即使相关的认知任务没有被执行（即在休息）。我们使用投射到源空间的脑磁图记录来证明，儿童时期的静息状态网络具有明显的电生理基础，这在振荡脑活动的自发波动中是显而易见的。使用这些振荡模式的时间结构，我们能够确定一些功能的静息态网络类似于成人文献中报道的。在第二次分析中，我们将这种动态时间信息与来自功能连接的功能磁共振成像分析的空间信息融合，以证明这些功能连接的电生理测量中的受试者间变异性与认知能力的个体差异相关：额顶叶网络和颞叶下皮层低级别处理区之间的连接强度与空间工作相关记忆能力，在扫描仪外用教育相关的标准化评估进行测量。这项研究代表了第一次探索的电生理机制，支持静息状态的源空间的功能连接在儿童时期，在何种程度上特定的连接的强度与认知能力。
Functional connectivity is the statistical association of neuronal activity time courses across distinct brain regions, supporting specific cognitive processes. This coordination of activity is likely to be highly important for complex aspects of cognition, such as the communication of fluctuating task goals from higher‐order control regions to lower‐order, functionally specific regions. Some of these functional connections are identifiable even when relevant cognitive tasks are not being performed (i.e. at rest). We used magnetoencephalographic recordings projected into source space to demonstrate that resting state networks in childhood have electrophysiological underpinnings that are evident in the spontaneous fluctuations of oscillatory brain activity. Using the temporal structure of these oscillatory patterns we were able to identify a number of functional resting state networks analogous to those reported in the adult literature. In a second analysis we fused this dynamic temporal information with the spatial information from a functional magnetic resonance imaging analysis of functional connectivity, to demonstrate that inter‐subject variability in these electrophysiological measures of functional connectivity is correlated with individual differences in cognitive ability: the strength of connectivity between a fronto‐parietal network and lower‐level processing areas in inferior temporal cortex was associated with spatial working memory capacity, as measured outside the scanner with educationally relevant standardized assessments. This study represents the first exploration of the electrophysiological mechanisms underpinning resting state functional connectivity in source space in childhood, and the extent to which the strength of particular connections is associated with cognitive ability.