Photoexcited state properties and antibacterial activities of carbon dots relevant to mechanistic features and implications
Photoexcited state properties and antibacterial activities of carbon dots relevant to mechanistic features and implications
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DOI：
10.1016/j.carbon.2020.08.025
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发表时间：
2020-12-01
期刊：
影响因子：
10.9
通讯作者：
Sun, Ya-Ping
中科院分区：
文献类型：
--
作者：
Dong, Xiuli;Ge, Lin;Sun, Ya-Ping
碳量子点（CDot）在可见光谱范围内具有强吸收性，有效的光子捕获驱动丰富的激发态过程和特性。在这项工作中，光谱探测这些过程和属性的CDots的光诱导杀菌功能的评价，旨在使从前者和那些从后者的细菌病原体的灭活的结果之间的相关性。在CDot的一般机制框架内，观察到的CDot在可见光下的有效和高效的抗菌活性归因于主要贡献的初始光生电子和空穴被捕获在钝化的表面缺陷位点的点，除了传统的活性氧物质（ROS）产生的发射激发态从氧化还原对的重组。CDot中分离的氧化还原物质对细菌灭活的这种主要贡献不能被经典分子光敏剂的光动力学效应研究中常用的ROS清除剂淬灭，从而使光活化CDot成为独特有效的抗微生物剂。结合传统半导体量子点的类似行为和机理模型，讨论了光激发CDots的特性及其相关的机理含义。(C)2020爱思唯尔有限公司保留所有权利。
Carbon dots (CDots) are strongly absorptive over the visible spectrum, with the effective photon-harvesting driving rich excited state processes and properties. In this work, spectroscopic probing of these processes and properties is coupled with the evaluation of the photoinduced bactericidal function of CDots, aimed toward making correlations among the findings from the former and those from the latter on the inactivation of bacterial pathogens. Within the general mechanistic framework for CDots, the observed effective and efficient antibacterial activities of the CDots under visible light are attributed to major contributions by the initially photo-generated electrons and holes that are trapped at passivated surface defect sites of the dots, in addition to the traditional reactive oxygen species (ROS) produced in the emissive excited states from the recombination of the redox pairs. Such major contributions to the inactivation of the bacteria by the separated redox species in CDots can not be quenched by ROS scavengers commonly used in the study of photodynamic effects with classical molecular photosensitizers, thus making light-activated CDots uniquely potent antimicrobial agents. The characteristic features of photoexcited CDots and their related mechanistic implications are discussed in reference to the similar behaviors and mechanistic model of conventional semiconductor quantum dots. (C) 2020 Elsevier Ltd. All rights reserved.