Using the cue-availability paradigm to assess cue reactivity
Using the cue-availability paradigm to assess cue reactivity
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DOI：
10.1097/01.alc.0000080666.89573.73
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发表时间：
2003-08-01
影响因子：
3.2
通讯作者：
Li, TK
中科院分区：
文献类型：
--
作者：
Davidson, D;Tiffany, ST;Li, TK
背景资料：最近一项关于线索反应性研究的荟萃分析显示，对酒精的特定线索渴望远不如对其他滥用药物的渴望强烈。酒精的小效应量强调了需要更强大的方法来评估人类的线索反应。线索可用性范式是一种修改传统的线索反应性范式，旨在增加测量线索反应性酒精在humans.Methods的敏感性：17个非寻求治疗的酗酒者分别进行了测试，在两个不同的会议（后启动酒精和后启动安慰剂酒精）。受试者共参加了32项线索可用性试验。在每一次试验中，受试者都被提供了一个目标线索（酒精）或一个中性线索（水）。每个线索可用于饮用50%的试验（可用性条件）。线索反应措施的渴望和mood.Results自我报告：酒精启动有强烈的影响渴望。无论消费的线索或线索的类型的可用性，渴望是一贯高于受试者与酒精比安慰剂酒精。在酒精刺激后进行评估时，消极情绪也更高。当酒精提示可供消费时，酒精引发的受试者的负面情绪减少。酒精暗示对渴望也有显著的影响，尽管影响较小。酒精线索一贯引起更高水平的渴望相对于水cue.Conclusions：这些数据表明，酒精的启动效应可能是一个显着的因素，促成的经验，渴望和维护饮酒。该研究还介绍了线索可用性作为一个额外的新方法，调查操纵的线索反应性酗酒。
Background: A recent meta-analysis on cue-reactivity research revealed that cue-specific craving for alcohol is substantially less robust than craving measured for other drugs of abuse. The small effect sizes for alcohol underscore the need for more powerful methods of as sessing cue reactivity in humans. The cue-availability paradigm is a modification of the conventional cue-reactivity paradigm and is intended to increase the sensitivity of measuring cue-reactivity to alcohol in humans.Methods: Seventeen non-treatment-seeking alcoholics were tested individually on two different sessions (after priming with alcohol and after priming with placebo-alcohol). Subjects were presented with a total of 32 cue-availability trials. On each trial, subjects were presented with either a target cue (alcohol) or a neutral cue (water). Each cue was available for drinking on 50% of the trials (availability condition). Cue-reactivity measures were self-reports of craving and mood.Results: The alcohol prime had a robust effect on craving. Irrespective of the availability of the cue for consumption or the type of cue, craving was consistently higher when subjects were primed with alcohol than with placebo-alcohol. Negative mood was also higher when it was assessed after the alcohol prime. Negative mood decreased in alcohol-primed subjects when the alcohol cue was available for consumption. The alcohol cue also had a significant, although more modest effect on craving. The alcohol cue consistently elicited higher levels of craving relative to the water cue.Conclusions: These data suggest that the priming effects of alcohol may be a significant factor contributing to the experience of craving and maintenance of drinking. The study also introduces the cue-availability as an additional new method for investigating manipulations of cue-reactivity in alcoholics.