Multi-modal MRI Reveals the Neurovascular Coupling Dysfunction in Chronic Migraine
Multi-modal MRI Reveals the Neurovascular Coupling Dysfunction in Chronic Migraine
复制标题
多模态 MRI 揭示慢性偏头痛的神经血管耦合功能障碍。
DOI：
10.1016/j.neuroscience.2019.09.022
复制
发表时间：
2019-11-01
期刊：
影响因子：
3.3
通讯作者：
Wang, Wen
中科院分区：
文献类型：
--
作者：
Hu, Bo;Yu, Ying;Wang, Wen
以往研究报道，长期伤害性刺激可导致脑内神经血管偶联（NVC）功能障碍，但这些研究主要基于单峰成像生物标志物，无法全面反映NVC功能障碍。我们通过探索神经元活动和脑灌注图之间的关系来研究慢性偏头痛中潜在的NVC功能障碍。这两个图谱之间的Pearson相关系数被定义为NVC生物标志物。偏头痛患者的NVC生物标志物在左侧顶叶下回（IPG）、左侧上边缘回（SMG）和左侧角回（AG）中显著降低，而在右侧枕上回（SOG）、右侧顶叶上回（SPG）和楔前叶中显著升高。这些脑区主要位于顶叶或枕叶，与视觉或感觉信息处理有关。右侧SPG ALFF-CBF与病史呈正相关，右侧楔前叶ALFF-CBF与偏头痛持续时间呈负相关。左上颌肌和AG的fALFF-CBF与头痛频率呈负相关，与健康状况和病史呈正相关。综上所述，多模态MRI可用于检测慢性偏头痛患者的NVC功能障碍，为评估慢性疼痛对大脑的影响提供了一种新的方法。(c) 2019 ibroElsevier Ltd.出版。版权所有。
Previous studies reported that long-term nociceptive stimulation could result in neurovascular coupling (NVC) dysfunction in brain, but these studies were based mainly on unimodal imaging biomarkers, thus could not comprehensively reflect NVC dysfunction. We investigated the potential NVC dysfunction in chronic migraine by exploring the relationship between neuronal activity and cerebral perfusion maps. The Pearson correlation coefficients between these 2 maps were defined as the NVC biomarkers. NVC biomarkers in migraineurs were significantly lower in left inferior parietal gyrus (IPG), left superior marginal gyrus (SMG) and left angular gyrus (AG), but significantly higher in right superior occipital gyrus (SOG), right superior parietal gyrus (SPG), and precuneus. These brain regions were located mainly in parietal or occipital lobes and were related to visual or sensory information processing. ALFF-CBF in right SPG was positively correlated with disease history and that in right precuneus was negatively correlated with migraine persisting time. fALFF-CBF in left SMG and AG were negatively related to headache frequency and positively related to health condition and disease history. In conclusion, multi-modal MRI could be used to detect NVC dysfunction in chronic migraine patients, which is a new method to assess the impact of chronic pain on the brain. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.