Body mass index, height and early-onset basal cell carcinoma in a case-control study.
Body mass index, height and early-onset basal cell carcinoma in a case-control study.
复制标题
在一项病例对照研究中，体重指数，高度和早发细胞癌。
DOI：
10.1016/j.canep.2016.12.007
复制
发表时间：
2017-02
影响因子：
2.6
通讯作者：
Ferrucci LM
中科院分区：
文献类型：
--
作者：
Zhang Y;Cartmel B;Choy CC;Molinaro AM;Leffell DJ;Bale AE;Mayne ST;Ferrucci LM
基底细胞癌（BCC）是美国最常见的恶性肿瘤。体重指数（BMI）和身高与多种癌症类型相关，但关于BCC的证据有限。因此，我们评估了BMI和身高与早发性BCC（40岁以下）的关系，并探讨了紫外线（UV）辐射暴露和雌激素相关暴露在BMI-BCC关系中的潜在作用。BCC病例（n=377）通过康涅狄格州的中央皮肤病理学机构确定。良性皮肤病对照组（n=389）从相同的数据库中随机抽样，频率与年龄（中位数=36，四分位数范围33-39），性别和活检部位的病例相匹配。参与者报告了体重（通常成人和18岁），成人身高，社会人口统计学，表型和医学特征，以及先前的紫外线暴露。我们使用非条件logistic回归模型计算多变量比值比（OR）和95%置信区间（CI）。成人BMI与早发性BCC呈负相关（肥胖与正常OR=0.43，95%CI =0.26-0.71）。18岁时BMI也存在类似的负相关（OR=0.54，95%CI =0.34-0.85）。从BMI模型中排除紫外线暴露并仅包括女性中的雌激素相关暴露并没有改变BMI和BCC之间的关联，表明有限的中介或混杂。我们没有观察到成人身高与基底细胞癌之间的相关性（OR/cm=1.00，95%CI =0.98-1.02）。我们发现BMI与早发性BCC之间呈显着负相关，但身高与BCC之间没有相关性。这种联系不能用紫外线照射或女性雌激素相关照射来解释。
Basal cell carcinoma (BCC) is the most common malignancy in the US. Body mass index (BMI) and height have been associated with a variety of cancer types, yet the evidence regarding BCC is limited. Therefore, we evaluated BMI and height in relation to early-onset BCC (under age 40) and explored the potential role of ultraviolet (UV) radiation exposure and estrogen-related exposures in the BMI-BCC relationship. BCC cases (n=377) were identified through a central dermatopathology facility in Connecticut. Control subjects (n=389) with benign skin conditions were randomly sampled from the same database and frequency matched to cases on age (median=36, interquartile range 33-39), gender, and biopsy site. Participants reported weight (usual adult and at age 18), adult height, sociodemographic, phenotypic, and medical characteristics, and prior UV exposures. We calculated multivariate odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models. Adult BMI was inversely associated with early-onset BCC (obese vs. normal OR=0.43, 95% CI=0.26-0.71). A similar inverse association was present for BMI at age 18 (OR=0.54, 95% CI=0.34-0.85). Excluding UV exposures from the BMI models and including estrogen-related exposures among women only did not alter the association between BMI and BCC, indicating limited mediation or confounding. We did not observe an association between adult height and BCC (OR per cm=1.00, 95% CI=0.98-1.02). We found a significant inverse association between BMI and early-onset BCC, but no association between height and BCC. This association was not explained by UV exposures, or estrogen-related exposures in women.