Subacute motor neuronopathy: A Remote effect of lymphoma
Subacute motor neuronopathy: A Remote effect of lymphoma
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亚急性运动神经元病：淋巴瘤的远程影响
DOI：
10.1002/ana.410050310
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发表时间：
1979
影响因子：
11.2
通讯作者：
J. Posner
中科院分区：
文献类型：
--
作者：
S. Schold;E. Cho;M. Somasundaram;J. Posner
10名患者发生亚急性下运动神经元综合征，作为霍奇金病或其他淋巴瘤的远期影响。这种疾病通常遵循一个良性的过程独立的活动的基础肿瘤。7例患者自发改善，3例神经功能正常。2例患者死于与免疫抑制相关的并发感染。这2例患者和3例先前报道的病例的神经病理学检查显示脊髓前角明显的神经元变性和轻度的后柱脱髓鞘。在我们的尸检病人的前根中也存在脱髓鞘，并伴有大的深染的雪旺细胞。这种疾病的原因尚不清楚，但放射治疗和机会性感染都可能是促成因素。病毒分离的尝试没有成功。该综合征应与淋巴瘤对神经系统更常见的直接影响区分开来，因为它的识别可以使患者免于额外的、可能有害的治疗。
Ten patients developed a subacute lower motor neuron syndrome as a remote effect of Hodgkin's disease or other lymphoma. The illness usually followed a benign course independent of the activity of the underlying neoplasm. Seven of the patients improved spontaneously, and 3 became neurologically normal. Two patients died of intercurrent infections related to immunosuppression. Neuropathological examination of these 2 patients and 3 previously reported cases showed prominent neuronal degeneration restricted to the anterior horns of the spinal cord and mild posterior column demyelination. Demyelination was also present in the anterior roots of our autopsied patients and was accompanied by large, hyperchromatic Schwann cells. The cause of the illness is obscure, but both radiation therapy and opportunistic infection may be contributing factors. Attempts at virus isolation have been unsuccessful. The syndrome should be distinguished from the more common direct effects of lymphoma on the nervous system, since its identification spares the patient additional, potentially harmful therapy.