Osteocyte-driven bone remodeling.
Osteocyte-driven bone remodeling.
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DOI：
10.1007/s00223-013-9774-y
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发表时间：
2014-01
影响因子：
4.2
通讯作者：
Bellido, Teresita
中科院分区：
文献类型：
--
作者：
Bellido, Teresita
骨细胞是骨中最丰富的细胞，长期以来一直被认为具有检测和响应机械和激素刺激以及协调成骨细胞和破骨细胞功能的作用。骨形成抑制剂sclerostin主要在骨中的骨细胞中表达并且其被合成代谢刺激下调的发现提供了骨细胞影响成骨细胞活性的机制。最近几年的研究进展提供了实验证据，证明骨细胞也参与破骨细胞的募集和骨重建的启动。凋亡的骨细胞触发尚未确定的信号，吸引破骨细胞前体到骨的特定区域，这反过来又分化为成熟的骨吸收破骨细胞。骨细胞也是调节破骨细胞生成和活性的分子（如OPG和RANKL）的来源;对小鼠基因组进行遗传操作，导致功能丧失或获得，或改变骨细胞中任一分子的表达，显著影响骨吸收。这篇综述强调了这些研究，并讨论了骨细胞驱动的骨吸收和形成的新概念如何影响我们对当前治疗控制骨重建机制的理解。
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. The discovery that the inhibitor of bone formation sclerostin is primarily expressed in osteocytes in bone and it is downregulated by anabolic stimuli provided a mechanism by which osteocytes influence the activity of osteoblasts. Advances of the last few years provided experimental evidence demonstrating that osteocytes also participate in the recruitment of osteoclasts and the initiation of bone remodeling. Apoptotic osteocytes trigger yet to be identified signals that attract osteoclast precursors to specific areas of bone, which in turn differentiate to mature, bone resorbing osteoclasts. Osteocytes are also the source of molecules that regulate generation and activity of osteoclasts, such as OPG and RANKL; and genetic manipulations of the mouse genome leading to loss or gain of function, or to altered expression of either molecule in osteocytes, markedly affect bone resorption. This review highlights these investigations and discusses how the novel concept of osteocyte-driven bone resorption and formation impacts our understanding of the mechanisms by which current therapies control bone remodeling.
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影响因子：
2.9
作者：
Igwe JC;Gao Q;Kizivat T;Kao WW;Kalajzic I
通讯作者：
Kalajzic I
影响因子：
4.1
作者：
Bellido, Teresita;Plotkin, Lilian I.
通讯作者：
Plotkin, Lilian I.
影响因子：
4.1
作者：
Jilka RL;Noble B;Weinstein RS
通讯作者：
Weinstein RS
影响因子：
4.8
作者：
Gortazar, Arancha R.;Martin-Millan, Marta;Bellido, Teresita
通讯作者：
Bellido, Teresita
DOI：
10.1016/j.bbrc.2004.06.056
发表时间：
2004-08-06
影响因子：
3.1
作者：
Bakker, A;Klein-Nulend, J;Burger, E
通讯作者：
Burger, E