Chromenes from the brown alga Sargassum siliquastrum
Chromenes from the brown alga Sargassum siliquastrum
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DOI：
10.1021/np058003i
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发表时间：
2005-05-01
影响因子：
5.1
通讯作者：
Shin, J
中科院分区：
文献类型：
--
作者：
Jang, KH;Lee, BH;Shin, J
Sargachromanols A-P (1-16) 是色烯类的 16 种新类萜，是从韩国济州岛采集的褐藻马尾藻 (siliquastrum) 中分离出来的。根据光谱和化学分析的综合结果，这些含苯并二氢吡喃醇化合物的聚异戊二烯部分的结构被确定为线性三异戊二烯基（1和2）和四异戊二烯基（3 -11），而其他部分分别是相应的重排（12-15）和环化（16）四异戊二烯基。新化合物在 DPPH 测定中表现出显着的抗氧化活性。化合物7和15也显示出对丁基胆碱酯酶的抑制活性。
Sargachromanols A-P (1-16), sixteen new meroterpenoids of the chromene class, were isolated from the brown alga Sargassum, siliquastrum collected from Jaeju Island, Korea. On the basis of the combined results of spectral and chemical analyses, the structures of the polyprenyl portions of these chromanol-containing compounds were determined to be linear triprenyls (1 and 2) and tetraprenyls (3 -11), while others were the corresponding rearranged (12-15) and cyclized (16) tetraprenyls, respectively. The new compounds exhibited significant antioxidant activity in the DPPH assay. Compounds 7 and 15 also showed inhibitory activity toward butylcholine esterase.