Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT.
Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT.
复制标题
使用 iodine-123-IMP 和 SPECT 定量绘制局部脑血流图。
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Uemura
中科院分区：
文献类型：
--
作者：
Hidehiro Lida;H. Itoh;M. Nakazawa;J. Hatazawa;H. Nishimura;Y. Onishi;Kazuo;Uemura
无标签
建立了静脉注射123I-N-异丙基-对碘苯丙胺(IMP)后SPECT单次扫描计算局部脑血流量(RCBF)功能图像的方法。
方法
采用包含局部脑血流量和IMP(Vd)局部分布体积两个参数的二室模型对IMP从脑中的清除进行了校正。使用给定的输入函数和固定的VD值(根据对动态SPECT数据的分析，为30ml/ml)，根据查表过程为SPECT图像的每个像素计算唯一的rCBF值。将该技术应用于15名受试者，并将计算的rCBF值与PET的测量值进行了比较。
结果
一组模拟研究表明，注射IMP后30至40分钟的SPECT扫描中期时间最佳，对输入功能的个体差异(rCBF值的准确度为+/-10%)提供了最小的误差敏感度。另一组模拟表明了固定VD值的有效性，即对于+/-10%的VD值的变化，计算的rCBF值的误差约为+/-7%。15名受试者的rCBF值与SPECT扫描时间无关。计算的rCBF值与动态SPECT扫描、频繁动脉采血和测定每个样本的亲脂部分(0.54+0.88x，r=0.86)的非线性最小二乘拟合分析的结果也符合得很好，表明该方法的简化步骤是有效的。
结论
这些观察结果表明，这种方法作为定量测量rCBF的临床工具是有效的。
UNLABELLED
A method was developed to calculate functional images of regional cerebral blood flow (rCBF) from a single scan using SPECT following intravenous 123I-N-isopropyl-p-iodoamphetamine (IMP) infusion.
METHODS
A two-compartment model that includes two parameters of rCBF and regional distribution volume of IMP (Vd) was employed to correct for clearance of IMP from the brain. Using a given input function and a fixed Vd value (30 ml/ml according to an analysis on dynamic SPECT data), a unique value of rCBF was calculated for each pixel of the SPECT image according to the table-look-up procedure. This technique was applied to 15 human subjects, and the calculated rCBF values were compared with those measured by PET.
RESULTS
A set of simulation studies demonstrated an optimal SPECT midscan time at 30 to 40 min postinjection of IMP, providing the minimal error sensitivity to the individual difference of the input function (rCBF values with an accuracy of +/- 10%). Another set of simulation suggested validity of fixing the Vd values, i.e., errors in calculated rCBF values were around +/- 7% for a change of Vd of +/- 10%. The measured rCBF values obtained from 15 human subjects were independent on the SPECT scan time. The calculated rCBF values also agreed well with those obtained by the nonlinear least-squares fitting analysis that were obtained from the dynamic SPECT scan and the frequent arterial blood sampling and measurement of lipophilic fraction for each sample (0.54 + 0.88x, r = 0.86), suggesting the validity of the simplified procedures in this method.
CONCLUSION
These observations suggested the validity of this method as a clinical tool for quantitative measurement of rCBF.