Lofexidine in the Treatment of Hypertension: A Twice‐Daily versus Once‐Daily Dose Comparison with 24‐Hour Blood Pressure Monitoring
Lofexidine in the Treatment of Hypertension: A Twice‐Daily versus Once‐Daily Dose Comparison with 24‐Hour Blood Pressure Monitoring
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洛非西定治疗高血压：每日两次与每日一次的剂量比较以及 24 小时血压监测
DOI：
10.1002/j.1552-4604.1981.tb05697.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
N. Kaplan
中科院分区：
文献类型：
--
作者：
B. Garrett;N. Kaplan
摘要：洛非西定，一种抗高血压的咪唑啉衍生物，给予10名高血压患者每日两次和每日一次的治疗方案，使用常规血压测量和24小时Remler记录。测定血浆肾素活性和儿茶酚胺。每日两次剂量滴定后，每日一次给予每日两次总剂量，持续两周，然后突然停药。平均安慰剂组仰卧位血压为136/104 mm Hg。每日两次治疗后，该值降至118/86 mm Hg，转换为每日一次治疗后，该值升至126/89 mm Hg。使用Remler记录仪，每日两次治疗期间的平均24小时血压为125/89 mmHg，每日一次治疗期间为133/94 mmHg，急性停药后当天为142/99 mmHg;即，在所有三个治疗期的评估显示缺乏持续控制，血压变化范围广且频率高。血浆肾素活性和血浆肾上腺素和去甲肾上腺素在研究期间没有显著变化。
Abstract: Lofexidine, an antihypertensive imidazoline derivative, was given to ten hypertensives on both a twice‐daily and once‐daily regimen, using routine blood pressure measurements and 24‐hour Remler recording. Plasma renin activity and catecholamines were measured. After a dose titration with twice‐daily doses, the total twice‐daily dose was given once daily for two weeks and the drug abruptly withdrawn. Mean placebo blood pressure was 136/104 mm Hg supine. After twice‐daily therapy, this fell to 118/86 mm Hg, and upon conversion to once‐daily therapy, it rose to 126/89 mm Hg. With the Remler recorder, mean 24‐hour blood pressure was 125/89 during the twice‐daily therapy, 133/94 mm Hg during once‐daily therapy, and 142/99 mm Hg on the day after acute withdrawal; i.e., evaluation in all three treatment periods showed a lack of sustained control with both a wide range and high frequency of blood pressure variation. Plasma renin activity and plasma epinephrine and norepinephrine did not change significantly during the study.