Molecular mechanisms of sex determination and gonadal sex differentiation in fish
Molecular mechanisms of sex determination and gonadal sex differentiation in fish
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DOI：
10.1007/s10695-006-7590-2
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发表时间：
2005-04-01
影响因子：
2.9
通讯作者：
Nagahama, Y.
中科院分区：
文献类型：
--
作者：
Nagahama, Y.
我们利用各种遗传和分子方法来研究鱼类性别决定和性腺性别分化的机制。经鉴定，DMY是medaka的性别决定基因。在罗非鱼中，内源性雌激素是卵巢分化的天然诱导剂，而DMRT1可能对睾丸分化很重要。使用基因或激素阻断策略确定了这些调节因子在性别决定和性腺性别分化中的作用。
We have used various genetic and molecular approaches to investigate the mechanisms of sex determination and gonadal sex differentiation in fish. DMY was identified as the sex-determining gene of medaka. In tilapia, endogenous estrogens act as natural inducers of ovarian differentiation, while DMRT1 may be important for testicular differentiation. The roles of these regulators in sex determination and gonadal sex differentiation were ascertained using a gene or hormonal blockade strategy.