Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex.
Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex.
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DOI：
10.1083/jcb.200806160
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发表时间：
2008-11-03
影响因子：
7.8
通讯作者：
Fasolo, Aldo
中科院分区：
文献类型：
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作者：
Giacobini, Paolo;Messina, Andrea;Morello, Francesca;Ferraris, Nicoletta;Corso, Simona;Penachioni, Junia;Giordano, Silvia;Tamagnone, Luca;Fasolo, Aldo
在哺乳动物中，生殖依赖于分泌神经肽促性腺激素释放激素-1(GnRH-1)的特定神经元。这些细胞起源于嗅觉胎盘的胚胎发育期间，并迁移到前脑，在那里它们成为下丘脑-垂体-性腺轴的组成部分。这一迁移过程受一系列指导信号的调控，这些信号允许GnRH-1细胞长途旅行，到达合适的目的地。Semaphorin4D(Sema4D)受体PlexinB1在发育中的嗅觉定位中高度表达，但其在这一背景下的功能仍不清楚。在这里，我们证明了PlexinB1缺陷的小鼠表现出GnRH-1神经元的迁移缺陷，导致成人大脑中这种细胞数量的减少。此外，Sema4D通过偶联PlexinB1和Met酪氨酸激酶(肝细胞生长因子受体)的激活来促进GnRH-1细胞的定向迁移。这项工作确定了PlexinB1在大脑发育过程中的一个功能，并提供了Sema4D控制GnRH-1神经元迁移的证据。
In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1 (GnRH-1). These cells originate during embryonic development in the olfactory placode and migrate into the forebrain, where they become integral members of the hypothalamic–pituitary–gonadal axis. This migratory process is regulated by a wide range of guidance cues, which allow GnRH-1 cells to travel over long distances to reach their appropriate destinations. The Semaphorin4D (Sema4D) receptor, PlexinB1, is highly expressed in the developing olfactory placode, but its function in this context is still unknown. Here, we demonstrate that PlexinB1-deficient mice exhibit a migratory defect of GnRH-1 neurons, resulting in reduction of this cell population in the adult brain. Moreover, Sema4D promotes directional migration in GnRH-1 cells by coupling PlexinB1 with activation of the Met tyrosine kinase (hepatocyte growth factor receptor). This work identifies a function for PlexinB1 during brain development and provides evidence that Sema4D controls migration of GnRH-1 neurons.
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影响因子：
--
作者：
Fazzari P;Penachioni J;Gianola S;Rossi F;Eickholt BJ;Maina F;Alexopoulou L;Sottile A;Comoglio PM;Flavell RA;Tamagnone L
通讯作者：
Tamagnone L
影响因子：
5.3
作者：
Deng, Suhua;Hirschberg, Alexandra;Kuner, Rohini
通讯作者：
Kuner, Rohini
影响因子：
4.8
作者：
Giacobini, P;Giampietro, C;Fasolo, A
通讯作者：
Fasolo, A
影响因子：
7.8
作者：
Oinuma, Izumi;Katoh, Hironori;Negishi, Manabu
通讯作者：
Negishi, Manabu
影响因子：
8
作者：
Corso, S.;Migliore, C.;Giordano, S.
通讯作者：
Giordano, S.