Effect of clonidine in obstructive sleep apnea.
Effect of clonidine in obstructive sleep apnea.
复制标题
可乐定在阻塞性睡眠呼吸暂停中的作用。
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
F. Issa
中科院分区：
文献类型：
--
作者：
F. Issa
目前治疗阻塞性睡眠呼吸暂停的首选方法是持续气道正压通气。然而，并不是所有的病人都能忍受这种治疗。我们评估了盐酸可乐定对8名男性阻塞性睡眠呼吸暂停患者的作用，盐酸可乐定是一种具有快速眼动抑制活性的α 2-肾上腺素能激动剂。在每名患者中，在10天的可乐定疗程中进行的两次通宵睡眠研究中，睡眠阶段分布和呼吸模式与对照组和安慰剂组的两个晚上进行了比较。睡前口服0.2毫克可乐定完全抑制了两名患者的快速眼动睡眠。在其他6名患者中，相同剂量的快速眼动睡眠时间从对照组的13.4 +/- 1.0减少到8.6 +/- 1.4%（平均+/- SEM， p < 0.05）。后一组进入快速眼动睡眠的潜伏期从对照组的129 +/- 9分钟增加到308 +/- 24分钟（p < 0.001）。可乐定对非快速眼动期呼吸异常的频率和持续时间没有影响。在可乐定治疗下，6例患者夜间低氧血症水平得到改善。这是由于两名患者的快速眼动完全被抑制，因此缺乏快速眼动呼吸暂停。4例患者在非抑制性快速眼动睡眠期间上气道阻塞消失，SaO2在整个睡眠阶段保持在90%以上。可乐定改变了另外两名患者在非抑制快速眼动期间睡眠呼吸障碍的模式，从重复性阻塞性低呼吸伴持续性低氧血症转变为闭塞性呼吸暂停和周期性低氧血症。在两项可乐定睡眠研究中，这些结果在所有患者中都得到了一致的观察。（摘要删节250字）
The current treatment of choice for obstructive sleep apnea is continuous positive airway pressure. However, not all patients tolerate this form of therapy. We evaluated the effect of clonidine hydrochloride, an alpha 2-adrenergic agonist with REM-suppressant activity, in eight male patients with obstructive sleep apnea. In each patient, sleep-stage distribution and breathing pattern in two all-night sleep studies performed during a 10-day course of clonidine were compared with those of two control and two placebo nights. A dose of 0.2 mg of clonidine administered orally at bedtime totally suppressed REM sleep in two patients. In the other six patients, the same dose decreased percent time spent in REM sleep from a control of 13.4 +/- 1.0 to 8.6 +/- 1.4% (mean +/- SEM, p less than 0.05). The latency to REM sleep increased in the latter group from a control of 129 +/- 9 to 308 +/- 24 min (p less than 0.001). Clonidine had no effect on the frequency and duration of non-REM breathing abnormalities. Under clonidine, the level of nocturnal hypoxemia improved in six patients. This was due to a total suppression of REM and the consequent lack of REM apneas in two patients. In four patients, upper airway obstruction disappeared during period of unsuppressed REM sleep, and SaO2 remained above 90% throughout this sleep stage. Clonidine transformed the pattern of sleep-disordered breathing during unsuppressed REM in the other two patients from that of repetitive obstructive hypopneas associated with persistent hypoxemia to occlusive apneas and cyclical hypoxemia. These results were observed consistently in all patients during both clonidine-sleep studies.(ABSTRACT TRUNCATED AT 250 WORDS)
上呼吸道和膈肌对化学刺激和负荷的反应。
DOI：
10.1152/jappl.1982.53.5.1133
发表时间：
1982
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Patrick,GB;Strohl,KP;Rubin,SB;Altose,MD
通讯作者：
Altose,MD