INVIVO EVALUATION OF MICROCIRCULATION BY COHERENT LIGHT-SCATTERING
INVIVO EVALUATION OF MICROCIRCULATION BY COHERENT LIGHT-SCATTERING
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DOI：
10.1038/254056a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
STERN, MD
中科院分区：
文献类型：
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作者：
STERN, MD
微循环在个体的代谢、血流动力学和热状态的调节中起着核心作用。它的生理状态在长时间和短时间内都有变化，反映了个体的健康状态；特别是在存在血管疾病或损伤的情况下，它是组织灌注是否充足的最终决定因素。由于这些原因，生理学家和临床医生都感兴趣的是能够快速，方便地监测微血管室中的流动状态和流动分布，并且对许多局部和中央反射控制的干扰最小。目前，这种测量依赖于直接观察、容积脉搏图、热测量或放射性同位素技术，这些技术要么缓慢，要么繁琐，要么严重干扰受试者的正常状态。我们在此报告了一种获取此类信息的非侵入性方法的发展的第一阶段，该方法具有快速反应和通过流速差异区分不同微血管室中的流动的潜在能力。
THE microcirculation plays a central role in the regulation of the metabolic, haemodynamic and thermal state of the individual. Its physiological state varies over both long and short time periods and reflects the state of health of the individual; in particular it is the ultimatearbiter of the adequacy of tissue perfusion in the presence of vascular disease or injury. For these reasons it is of interest to both the physiologist and the clinician to be able to monitor the state of flow and distribution of flow in the compartments of the microvasculature rapidly, conveniently and with minimal interference with the many local and central reflex controls. At present such measurements depend on direct observation, plethysmography thermal or radioisotope techniques1, which are slow or cumbersome or grossly disturb the normal state of the subject. We report here the first stages in development of a noninvasive method for acquiring such information which has a rapid response and the potential ability to distinguish flow in the different microvascular compartments by the differences in flow velocities.