10-YEAR MORTALITY STUDY OF THE POPULATION INVOLVED IN THE SEVESO INCIDENT IN 1976
10-YEAR MORTALITY STUDY OF THE POPULATION INVOLVED IN THE SEVESO INCIDENT IN 1976
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DOI：
10.1093/oxfordjournals.aje.a115240
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发表时间：
1989-06-01
影响因子：
5
通讯作者：
RADICE, L
中科院分区：
文献类型：
--
作者：
BERTAZZI, PA;ZOCCHETTI, C;RADICE, L
1976年，意大利塞维索附近的一家工厂发生意外爆炸，导致人口稠密地区受到2，3，7，8-四氯二苯并对二恶英（TCDD）的污染。该地区被细分为三个区域（A，B，R）具有降低的TCDD土壤污染的平均水平。本研究调查了1976年至1986年期间，事故发生后居住在该地区的20-74岁受试者的死亡率（A区n = 556，B区n = 3,920，R区n = 26,227）。受试者的暴露按居住地分类。同时检查了居住在周围环境中的167，391名受试者的参考队列。超过99%的受试者成功确定了生命状态。心血管原因导致的死亡率增加;与TCDD暴露相比，与事件相关的应激因素被认为与死亡率增加更相关。几种癌症的死亡率上升。胆管癌（女性）、脑癌以及淋巴和造血肿瘤（尤其是男性中的白血病）的增加似乎不是偶然、混杂或信息/比较偏倚所致。然而，与暴露分类有关的明确模式并不明显。还观察到软组织肿瘤和黑色素瘤仅提示性增加。肝癌和乳腺癌死亡率往往低于预期。由于观察期短、某些原因造成的死亡人数少以及暴露定义不明确，因此无法进行解释。进一步的研究正在进行中。
In 1976, an accidental explosion in a plant near Seveso, Italy, caused the contamination of a populated area by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The area was subdivided into three zones (A, B, and R) having decreasing mean levels of TCDD soil contamination. This study examines the mortality between 1976 and 1986 among the subjects, aged 20-74 years, who were resident in the area since the accident (n = 556 in zone A, n = 3,920 in zone B, n = 26,227 in zone R). Subjects'' exposure was classified by residence. A referent cohort of 167,391 subjects who lived in the immediate surroundings was concurrently examined. Vital status ascertainment was successful for over 99% of the subjects. Increased mortality from cardiovascular causes was found; incident-related stressors were considered more relevant to increased mortality than was TCDD exposure. Mortality from several cancers was elevated. The increases in biliary cancer (females), brain cancer, and lymphatic and hemopoietic neoplasms (particularly leukemia in males) did not appear to result from chance, confounding, or information/comparison bias. However, no definite patterns related to exposure classification were apparent. Merely suggestive increases in soft tissue tumors and melanoma were also noted. Liver and breast cancer mortality tended to be below expectations. Interpretation is hampered by the short observation period, small number of deaths from certain causes, and poor exposure definition. Further research is in progress.