COMPARISON OF NITROGEN-MUSTARD-SENSITIVE AND -RESISTANT YOSHIDA SARCOMAS
COMPARISON OF NITROGEN-MUSTARD-SENSITIVE AND -RESISTANT YOSHIDA SARCOMAS
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DOI：
10.1002/ijc.2910010403
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发表时间：
1966-01-01
影响因子：
6.4
通讯作者：
WHISSON, ME
中科院分区：
文献类型：
--
作者：
BALL, CR;CONNORS, TA;WHISSON, ME
从染色体数目、生长速度、核酸、蛋白质和游离硫醇含量等方面比较了吉田肉瘤及其衍生株对烷化剂的获得性抗性。尽管已经证明对烷化剂马法兰的耐药性至少是敏感菌株的100倍，但到目前为止，这两种肿瘤在所有研究方面都非常相似。到目前为止，固体耐药肿瘤的唯一不同之处是谷胱甘肽含量略有增加，但不是非常显著。
The Yoshida sarcoma and a line derived from it showing acquired resistance to alkylating agents have been compared from a number of aspects: chrbmosome number, growth rate, nucleic acid, protein and free thiol content. Although the degree of resistance to the alkylating agent Melphalan has been demonstrated to be at least 100 times greater than the sensitive strain, the 2 tumors have been very similar in all aspects so far studied. A small, and not highly significant, increase in glutathione content of the solid resistant tumor has been the only difference so far demonstrated.