CORRELATION BETWEEN LEFT FRONTAL PHOSPHOLIPIDS AND WISCONSIN CARD SORT TEST-PERFORMANCE IN SCHIZOPHRENIA
CORRELATION BETWEEN LEFT FRONTAL PHOSPHOLIPIDS AND WISCONSIN CARD SORT TEST-PERFORMANCE IN SCHIZOPHRENIA
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DOI：
10.1016/0920-9964(94)00036-8
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发表时间：
1995-01-01
影响因子：
4.5
通讯作者：
WEINER, MW
中科院分区：
文献类型：
--
作者：
DEICKEN, RF;MERRIN, EL;WEINER, MW
在16名慢性精神分裂症患者和13名正常对照者中，研究了额叶磷脂测量值（通过体内（31）磷磁共振光谱成像测量）与威斯康星州卡片分类测试表现之间的关系。精神分裂症患者左额叶磷酸单酯水平较低，与较少的类别实现，较低的百分比概念水平，更大的总错误。在对照组中，额叶磷脂测量值与WCST表现之间无显著相关性。结果表明，左额叶磷脂代谢的改变与额叶神经心理功能的特定测量之间存在关系。
The relationship between frontal lobe phospholipid measures as measured by in vivo (31)phosphorus magnetic resonance spectroscopic imaging and performance on the Wisconsin Card Sort Test was examined in 16 chronic schizophrenic patients and 13 normal controls. Lower left frontal phosphomonoester levels in the schizophrenics were associated with fewer categories achieved, lower percent conceptual level, and greater total errors. No significant correlations between frontal phospholipid measures and performance on the WCST were noted in the controls. The results suggest a relationship between altered left frontal phospholipid metabolism and a specific measure, of frontal lobe neuropsychological functioning.