Magnetic Resonance Spectroscopy of the Normal Cerebellum: What Degree of Variability Can Be Expected?
Magnetic Resonance Spectroscopy of the Normal Cerebellum: What Degree of Variability Can Be Expected?
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DOI：
10.1007/s12311-012-0415-1
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发表时间：
2013-04-01
期刊：
影响因子：
3.5
通讯作者：
Hoggard, Nigel
中科院分区：
文献类型：
--
作者：
Currie, Stuart;Hadjivassiliou, Marios;Hoggard, Nigel
本文的目的是：（a）使用适合临床放射学限制的方法，建立小脑H-1-MR波谱测定的相对代谢物浓度的可靠性;（B）记录小脑内代谢物的正常值，并寻找小脑半球白色物质和上级蚓部之间代谢物浓度的差异。采用PRESS序列（TR/TE = 2，000/144 ms），对55名健康成人（平均年龄41岁，范围20 ~ 77岁）的右侧小脑半球白色物质和上级蚓部的体素进行3-TH-1-MR波谱分析。一名志愿者（男性，年龄34岁）在3周的时间内接受了6次单独的检查。通过评价变异系数（%）确定受试者内和受试者间代谢物拟合面积比的可靠性。与半球（7.2 - 14.3）相比，蚓部（4 - 11.6）中代谢物比值的受试者间和受试者内变异系数（%）始终较低。与半球（0.76 +/-0.11）相比，蚓部（0.83 +/-0.10）的Cho/Cr显著较高，与半球（1.35 +/- 0.16）相比，蚓部（1.19 +/- 0.12）的NAA/Cho显著较低。当使用适合于临床放射学的时间限制的H-1-MR光谱技术时，可以实现低的受试者间和受试者内变异性。在进行疾病研究时，应考虑大脑半球和小脑蚓部内Cho/Cr和NAA/Cho的区域变化，这可能优先针对特定的小脑位置。
The objectives of this paper are (a) to establish the reliability of relative metabolite concentrations determined with H-1-MR spectroscopy of the cerebellum using a method appropriate to the constraints of clinical radiology and (b) to record normal values for metabolites within the cerebellum and to look for differences in metabolite concentrations between the cerebellar hemispheric white matter and the superior vermis. 3-T H-1-MR spectra were obtained from voxels positioned in the right cerebellar hemispheric white matter and the superior vermis in 55 healthy adults (mean age 41 years, range 20 to 77) using a single voxel PRESS sequence (TR/TE = 2,000/144 ms). One volunteer (male, age 34 years) was examined in six separate sessions over a period of 3 weeks. Reliability of intra- and inter-subject metabolite fitted area ratios was determined by evaluating coefficients of variance (%). Inter- and intra-subject coefficients of variance (%) in metabolite ratios were consistently lower in the vermis (4 to 11.6) compared to those of the hemisphere (7.2 to 14.3). Cho/Cr was significantly higher in the vermis (0.83 +/- 0.10) compared to the hemisphere (0.76 +/- 0.11) and NAA/Cho was significantly lower in the vermis (1.19 +/- 0.12) compared to the hemisphere (1.35 +/- 0.16). Low inter- and intra-subject variability can be achieved when using a H-1-MR spectroscopy technique that is appropriate to the time constraints of clinical radiology. The regional variations of Cho/Cr and NAA/Cho within the hemisphere and vermis should be considered when performing studies of diseases, which may preferentially target a particular cerebellar location.