Delta Opioid Pharmacology in Relation to Alcohol Behaviors.
Delta Opioid Pharmacology in Relation to Alcohol Behaviors.
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DOI：
10.1007/164_2016_30
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发表时间：
2018
影响因子：
--
通讯作者：
van Rijn, Richard M
中科院分区：
文献类型：
--
作者：
Alongkronrusmee, Doungkamol;Chiang, Terrance;van Rijn, Richard M
δ阿片受体（DORs）在大脑中大量参与酒精介导的过程。在本章中，我们概述了酒精如何直接影响DOR药理学的研究，以及表明酒精行为调节DOR的早期研究。我们将简要介绍在调查DORs的酒精研究中使用的不同动物物种，然后对DORs调节的酒精行为类型进行更广泛的概述。我们将重点介绍一小组研究酒精和DORs在镇痛中的关系。然后，我们将提供一个解剖学概述，将DOR在特定大脑区域的表达与不同的酒精行为联系起来。在本节中，我们将提供两个模型，试图解释内源性阿片类药物如何作用于DORs影响酒精行为。接下来，我们将概述研究DOR药理学的某些新方面，包括异聚体的形成和偏置信号。最后，我们简要概述了与酒精使用障碍（AUDs）相关的DORs遗传学，并简要说明了使用基于酒精使用障碍的治疗方法治疗AUDs的潜力。
Delta opioid receptors (DORs) are heavily involved in alcohol-mediated processes in the brain. In this chapter we provide an overview of studies investigating how alcohol directly impacts DOR pharmacology and of early studies indicating DOR modulation of alcohol behavior. We will offer a brief summary of the different animal species used in alcohol studies investigating DORs followed by a broader overview of the types of alcohol behaviors modulated by DORs. We will highlight a small set of studies investigating the relationship between alcohol and DORs in analgesia. We will then provide an anatomical overview linking DOR expression in specific brain regions to different alcohol behaviors. In this section, we will provide two models that try to explain how endogenous opioids acting at DORs may influence alcohol behaviors. Next, we will provide an overview of studies investigating certain new aspects of DOR pharmacology, including the formation of heteromers and biased signaling. Finally, we provide a short overview of the genetics of the DORs in relation to alcohol use disorders (AUDs) and a short statement on the potential of using DOR-based therapeutics for treatment of AUDs.