MITOCHONDRIAL FUNCTION IN SEPSIS.
MITOCHONDRIAL FUNCTION IN SEPSIS.
复制标题
DOI：
10.1097/shk.0000000000000463
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
ADQI XIV Workgroup
中科院分区：
文献类型：
--
作者：
Arulkumaran N;Deutschman CS;Pinsky MR;Zuckerbraun B;Schumacker PT;Gomez H;Gomez A;Murray P;Kellum JA;ADQI XIV Workgroup
线粒体是细胞基础结构的重要组成部分，是通过氧化磷酸化产生高能三磷酸腺苷（ATP）的主要场所。显然，在严重的全身性炎症状态下，如脓毒症，细胞代谢通常发生改变，终末器官功能障碍不仅常见，而且可预测长期发病率和死亡率。很明显，线粒体作为细胞内损伤的靶点和对外源性应激的反应的功能一直是基础科学和临床研究急性疾病病理生理学的主要焦点。然而，线粒体具有多种代谢和信号传导功能，可能是脓毒症的表达及其最终结果的中心。在这篇综述中，作者讨论了围绕线粒体在脓毒症中的作用的五个主要问题。这篇综述既可以作为急性疾病背景下线粒体生理学的总结来源，也可以作为这些见解提供的诊断和治疗机会的新研究的焦点。
Mitochondria are an essential part of the cellular infrastructure, being the primary site for high energy adenosine triphosphate (ATP) production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered and end organ dysfunction not only common but predictive of long term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used as both a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide.