Cyclic muscle twitch contraction inhibits immobilization-induced muscle contracture and fibrosis in rats
Cyclic muscle twitch contraction inhibits immobilization-induced muscle contracture and fibrosis in rats
复制标题
周期性肌肉抽搐抑制大鼠固定引起的肌肉挛缩和纤维化
DOI：
10.1080/03008207.2016.1257004
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发表时间：
2017
影响因子：
2.9
通讯作者：
Okita M
中科院分区：
文献类型：
--
作者：
Yoshimura A;Sakamoto J;Honda Y;Kataoka H;Nakano J;Okita M
我们研究了神经肌肉电刺激(NMES)引起的周期性肌肉抽动收缩对制动诱导的大鼠肌肉痉挛和纤维化的影响。将29只大鼠分为对照组、制动组和肌肉收缩制动组。制动和肌肉收缩大鼠的踝关节在足底完全屈曲状态下石膏固定4周。在肌肉收缩组，使用商用装置(1 Hz，4±2 mA，60min/d，5次/周)诱导比目鱼肌周期性收缩，并固定踝关节。肌肉收缩组踝关节活动的背屈幅度明显大于制动组。与制动组相比，肌肉收缩组纤维化相关基因(缺氧诱导因子-1α、转化生长因子-β1、α-平滑肌肌动蛋白、I型和III型胶原)的表达显著降低。肌肉收缩组肌束膜和肌内膜的I型和III型胶原的荧光强度较制动组明显减弱。这些结果表明，NMES诱导的周期性肌肉抽动收缩可能减轻骨骼肌纤维化，减少制动诱导的肌肉痉挛。
We investigated the effects of cyclic muscle twitch contraction caused by neuromuscular electrical stimulation (NMES) on immobilization-induced muscle contracture and fibrosis in rats. Twenty-nine rats were divided into control, immobilization, and immobilization with muscle contraction groups. The ankle joints of the immobilization and muscle contraction rats were fixed in full plantar flexion with a plaster cast for 4 weeks. In the muscle contraction group, cyclic muscle twitch contraction of the soleus muscle was induced using a commercial device (1 Hz, 4 ± 2 mA, 60 min/day, 5 times/week) with the ankle joint immobilized. The dorsiflexion range of ankle joint motion in the muscle contraction group was significantly greater than that in the immobilization group. The expressions of fibrosis-related genes (i.e., hypoxia inducible factor-1α, transforming growth factor-β1, α-smooth muscle actin, and types I and III collagen) were significantly decreased in the muscle contraction group compared to the immobilization group. The fluorescence intensities of type I and type III collagen in the perimysium and endomysium in the muscle contraction group were significantly decreased compared to the immobilization group. These results suggest that cyclic muscle twitch contraction induced by NMES might alleviate skeletal muscle fibrosis, reducing immobilization-induced muscle contracture.
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影响因子：
6.4
作者：
Biao Hu;Zhe Wu;S. Phan
通讯作者：
Biao Hu;Zhe Wu;S. Phan
固定化对大鼠比目鱼肌胶原蛋白的影响
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
Hara;Yukihiro;Banno Y;原 行弘;Inoue T;Hara Yukihiro;Hara Yukihiro;Hibino I
通讯作者：
Hibino I
肢体延长手术过程中兔胫骨前肌僵硬度增加的形态学基础
影响因子：
2.4
作者：
P. Williams;P. Kyberd;H. Simpson;J. Kenwright;G. Goldspink
通讯作者：
G. Goldspink
DOI：
10.1016/s0003-9993(97)90166-0
发表时间：
1997-05
影响因子：
4.3
作者：
L. Qin;H. Appell;K. Chan;N. Maffulli
通讯作者：
L. Qin;H. Appell;K. Chan;N. Maffulli
固定肌肉中的结缔组织发生变化。
影响因子：
2.4
作者：
P. Williams;G. Goldspink
通讯作者：
G. Goldspink