Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes
Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes
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DOI：
10.1111/1753-0407.12777
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发表时间：
2018-11-01
影响因子：
4.5
通讯作者：
Sobngwi, Eugene
中科院分区：
文献类型：
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作者：
Lontchi-Yimagou, Eric;Legoff, Jerome;Sobngwi, Eugene
背景：病毒被认为是糖尿病发展的潜在触发因素。本研究评估胰岛素分泌和胰岛素敏感性在人类疱疹病毒8（HHV 8）感染和未感染的撒哈拉以南非洲人diabetes.Methods：在所有，173人与非自身免疫性糖尿病连续入组：124与2型糖尿病（T2 DM）和49与酮症倾向糖尿病（KPD）承认高血糖危象。KPD患者进一步分为新发酮症期KPD（n = 34）和非酮症期KPD（n = 15）。所有参与者都进行了HHV 8特异性抗体和基因组DNA筛查。结果：在173例糖尿病患者中，88例（50.9%）HHV 8抗体阳性（Ac-HHV 8+），其中15例（8.7%）HHV 8 DNA阳性（DNA-HHV 8+）。T2 DM（55.6%）和KPD（61.2%）受试者之间的HHV 8血清阳性率相似。在有和没有酮症相KPD的患者中，Ac-HHV 8+分别占35.3%和46.7%。DNA-HHV 8+受试者的体重指数显著低于DNA-HHV 8-受试者。低密度脂蛋白和总胆固醇显着较高，但C-肽和β细胞功能的稳态模型评估（HOMA-β）显着低于DNA-HHV 8-参与者。在排除DNA-HHV 8+参与者后，Ac-HHV 8+（n = 73）受试者的甘油三酯浓度显著高于Ac-HHV 8-（n = 85）受试者。相比之下，HOMA-β显着高于Ac-HHV 8+比Ac-HHV 8-participators.Conclusions：在本研究中，HHV 8 DNA阳性与低胰岛素分泌在撒哈拉以南非洲糖尿病人群。
Background: Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes.Methods: In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment.Results: Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8- subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of beta-cell function (HOMA-beta) were significantly lower in DNA-HHV8+ than DNA-HHV8- participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8- (n = 85) subjects. In contrast, HOMA-beta was significantly higher among Ac-HHV8+ than Ac-HHV8- participants.Conclusions: In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.