On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.
On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.
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DOI：
10.1038/srep42766
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发表时间：
2017-02-21
影响因子：
4.6
通讯作者：
Eanes WF
中科院分区：
文献类型：
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作者：
Cogni R;Kuczynski K;Koury S;Lavington E;Behrman EL;O'Brien KR;Schmidt PS;Eanes WF
关于自然种群遗传变异的长期变化的信息很少。在这里，我们采取的独特的机会，比较一组数据的SNPs在15个代谢基因从美国东部的集合的果蝇，跨越一个大的纬度范围，代表两个集合分开12至13年。我们还将其扩展到Adh基因的22年间隔和G6pd和Pgd基因的约30年间隔。在这些时间间隔内，5个基因显示出统计学上显著的变化，平均SNP等位基因频率校正纬度。虽然大部分保持不变，我们看到五个基因的纬度倾斜已经失去或获得和两个斜率显着变化。在澳大利亚人群中报告的向南方有利的Adh S等位基因的长期频率偏移在美国东部没有观察到超过21年的时间。在基因中，南方偏好或北方偏好的等位基因频率增加的一般模式并不存在。这一观察结果表明，在这段时间内，一些等位基因变异的流动性以及选择性反应或迁移的作用可能更具区域性，而不是在整个渐变群中均匀施加。
Very little information exists for long-term changes in genetic variation in natural populations. Here we take the unique opportunity to compare a set of data for SNPs in 15 metabolic genes from eastern US collections of Drosophila melanogaster that span a large latitudinal range and represent two collections separated by 12 to 13 years. We also expand this to a 22-year interval for the Adh gene and approximately 30 years for the G6pd and Pgd genes. During these intervals, five genes showed a statistically significant change in average SNP allele frequency corrected for latitude. While much remains unchanged, we see five genes where latitudinal clines have been lost or gained and two where the slope significantly changes. The long-term frequency shift towards a southern favored Adh S allele reported in Australia populations is not observed in the eastern US over a period of 21 years. There is no general pattern of southern-favored or northern-favored alleles increasing in frequency across the genes. This observation points to the fluid nature of some allelic variation over this time period and the action of selective responses or migration that may be more regional than uniformly imposed across the cline.