Differential responses of tissue viscance and collateral resistance to histamine and leukotriene C4.
Differential responses of tissue viscance and collateral resistance to histamine and leukotriene C4.
复制标题
组织活力和对组胺和白三烯 C4 的附带抵抗力的差异反应。
DOI：
10.1152/jappl.1988.65.3.1424
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Drazen,JM
中科院分区：
文献类型：
--
作者：
Ludwig,MS;Shore,SA;Fredberg,JJ;Drazen,JM
组织黏度（Vti）和侧支阻力（Rcoll）的改变都被用作外周肺反应的指标。然而，尚不清楚这两种反应是否反映了相同收缩元素激活的影响。我们测量了Vti和Rcoll对组胺和白三烯（LT） C4的不同反应，以确定每种反应是否引起相似的反应模式。采用楔形支气管镜恒流技术测量麻醉、麻痹、开胸、机械通气的杂种狗大叶段的Rcoll。此外，我们（用肺泡囊）测量了所研究节段内的肺泡压力（PA）。这使我们能够计算Vti，即PA随段流相变化的分量。Rcoll和Vti测量是在基线条件下和局部输送组胺和LTC4产生的气溶胶后获得的。在同时使用组胺和LTC4的5个脑叶中，有5个脑叶对组胺的分数Rcoll反应大于对LTC4的分数Rcoll反应。相反，在检查的5个脑叶中有4个，Vti伴随组胺反应的分数增加小于LTC4给药时Vti的分数增加。这些数据表明，解剖学上不同的收缩因子影响着Vti和Rcoll，因为LTC4和组胺在肺外周反应的这两个指标中引起了定量的不同变化。
Alterations in tissue viscance (Vti) and collateral resistance (Rcoll) are both used as indexes of peripheral lung responses. However, it is not known whether the two responses reflect the effects of activation of the same contractile elements. We measured differential responses in Vti and Rcoll to histamine and leukotriene (LT) C4 to determine whether each evoked a similar pattern of response. Using the wedged bronchoscope constant-flow technique, we measured Rcoll in lobar segments of anesthetized, paralyzed, open-chest, mechanically ventilated mongrel dogs. In addition, we measured (with an alveolar capsule) alveolar pressure (PA) within the segment under study. This allowed us to calculate Vti, the component of the PA change in phase with segment flow. Rcoll and Vti measurements were obtained under base-line conditions and after local delivery of aerosols generated from histamine and LTC4. In five out of five lobes studied with both histamine and LTC4, the fractional Rcoll response to histamine was greater than the fractional Rcoll response to LTC4. In contrast, in four out of five lobes examined, the fractional increase in Vti accompanying the histamine response was less than the fractional increase in Vti accompanying LTC4 administration. These data suggest that anatomically distinct contractile elements influence Vti and Rcoll insofar as LTC4 and histamine evoke quantitatively different changes in these two indexes of peripheral lung responses.