Isolation and Antibiotic Susceptibility Pattern of Escherichia coli from Urinary Tract Infections in a Tertiary Care Hospital of North Eastern Karnataka.
Isolation and Antibiotic Susceptibility Pattern of Escherichia coli from Urinary Tract Infections in a Tertiary Care Hospital of North Eastern Karnataka.
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DOI：
10.4103/0976-9668.210012
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发表时间：
2017-07-01
期刊：
影响因子：
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通讯作者：
Sailesh, Kumar Sai
中科院分区：
文献类型：
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作者：
Kulkarni, Sudheendra Ramesh;Peerapur, Basavaraj V;Sailesh, Kumar Sai
简介：尿路感染 (UTI) 的临床管理受到抗菌药物易损性模式的影响。 目的：本研究旨在分析 2012 年至 2015 年 4 年间引起 UTI 的大肠杆菌 (E. coli) 的耐药模式。 材料和方法：收集疑似尿路感染患者的 1000 份样本，并进行培养和抗菌药物敏感性分析。按常规微生物学技术进行。结果：1000份样品中，395份大肠杆菌培养阳性。通过纸片扩散法测试这些分离株的抗生素敏感性。在总共 395 株大肠杆菌分离株中，170 株（43%）具有多重耐药性 (MDR)。分离株对氨苄青霉素（82.53%）、头孢呋辛（72.41%）、阿莫西林克拉维酸（71.90%）、头孢曲松（66.58%）、环丙沙星（65.82%）和头孢吡肟（57.47%）表现出高水平的耐药性。分离株对亚胺培南（96.71%）、呋喃西林（92.41%）、阿米卡星（90.89%）、氯霉素（85.82%）、哌拉西林他唑巴坦（80.76%）、庆大霉素（59.24%）、阿西曲南（54.43%）和诺氟沙星敏感。 (53.67%)。结论：我们的结论是，我们的研究对象中有相当一部分尿路感染是由多重耐药大肠杆菌引起的。从 2012 年到 2015 年，敏感性模式持续下降，亚胺培南是目前最有效的抗生素。
INTRODUCTION: Clinical management of the urinary tract infections (UTI) is influenced by the antimicrobial vulnerability patterns.OBJECTIVE: The study aimed to analyse the resistance pattern of the Escherichia coli (E. coli) causing UTI in patients over a period of 4 years from 2012 to 2015.MATERIALS AND METHODS: 1000 samples from patients suspected of having urinary tract infections were collected and processed for culture and antimicrobial drug susceptibility as per the routine microbiological techniques.RESULTS: Of the total 1000 samples, 395 cases were culture-positive for E. coli. These isolates were tested for antibiotic susceptibility by disk diffusion method. Of the total 395 E. coli isolates, 170 (43%) were multi drug resistant (MDR). The isolates showed high level of resistance to Ampicillin (82.53%), Cefuroxime (72.41%), Amoxycillin-clavulinic acid (71.90%), Ceftriaxone (66.58%), Ciprofloxacin (65.82%) and Cefepime (57.47%). The isolates were sensitive to Imipenem (96.71%), Nitrfurantion (92.41%), Amikacin (90.89%), Chloramphenicol (85.82%), Piperacillin-tazobactum (80.76%), Gentamicin (59.24%), Azetreonam (54.43%) and Norfloxacin (53.67%).CONCLUSION: We conclude that a significant number of the urinary tract infections in our study subjects were caused by multiple drug resistant E. coli. The sensitivity pattern showed a continued decline from 2012 to 2015, with Imipenem being currently the most effective antibiotic.