Hospital or population controls for case-control studies of severe childhood diseases?
Hospital or population controls for case-control studies of severe childhood diseases?
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DOI：
10.1093/aje/kwf174
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发表时间：
2003-01-15
影响因子：
5
通讯作者：
Infante-Rivard, C
中科院分区：
文献类型：
--
作者：
Infante-Rivard, C
很少有经验数据来确定哪一个对照组似乎是最好的病例对照研究中的严重疾病：人口控制或医院控制。作者于1980年至1993年在加拿大魁北克进行了一项儿童白血病病例对照研究，使用两个对照组，即人群对照组和医院对照组（白血病和严重血液病以外的癌症）。选择与白血病无关的母亲、父亲和儿童因素以及可能相关的因素进行分析。大多数因素直接从父母的访谈，但两个因素有关的父母职业暴露的化学家盲目编码。医院和人群对照组采用logistic回归估计的比值比进行比较。病例组与两组对照组采用相同的统计学方法进行比较。正在进行的人口调查的患病率数据与控制报告的患病率进行了比较。从以前的比较和社会经济变量的分布，结果表明，研究小组来了。来自同一个人口基数。然而，报告和编码，医院对照组的暴露量更接近病例组，而不是人群对照组。虽然只有一个因素有很大的不同，但使用医院对照与人群对照进行的推断导致优势比更接近零值。
There are few empirical data to determine which control group seems best in a case-control study for a severe disease: population controls or hospital controls. The author conducted a case-control study of leukemia in children using two control groups, population and hospital controls (cancers other than leukemia and severe blood diseases), between 1980 and 1993 in Quebec, Canada. Maternal, paternal, and child factors not known to be associated with leukemia as well as factors possibly associated were selected for analysis. Most factors were taken directly from parental interviews, but two factors related to parental occupational exposures were blindly coded by chemists. Hospital and population controls were compared using odds ratios estimated from logistic regression. Cases were compared with both types of controls with the same statistical method. Prevalence data from ongoing population surveys were compared with reported prevalence in controls. From the former comparisons and the distribution of socioeconomic variables, results suggested that study groups came. from the same base population. Nevertheless, reported and coded,exposures among hospital controls were closer to those of cases than to those of population controls. Although substantially different for only one factor, inferences using hospital controls in comparison with population controls resulted in odds ratios closer to the null value.