Escape swim network interneurons have diverse roles in behavioral switching and putative arousal in Pleurobranchaea
Escape swim network interneurons have diverse roles in behavioral switching and putative arousal in Pleurobranchaea
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DOI：
10.1152/jn.2000.83.3.1346
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发表时间：
2000-03-01
影响因子：
2.5
通讯作者：
Gillette, R
中科院分区：
文献类型：
--
作者：
Jing, J;Gillette, R
在掠食性海蛞蝓中游泳。是一种凌驾于进食之上的主导行为，是由游泳诱导的进食命令神经元抑制引起的一种行为转换。我们现在已经发现了不同的游泳中间神经元在游泳过程中对摄食的急性抑制和对摄食网络兴奋性的长期刺激中所起的不同作用。已确定的产生模式的游泳神经元Al， A3， A10和它们的跟随中间神经元A-ci1，部分通过I1喂养中间神经元的兴奋抑制摄食运动输出，I1喂养中间神经元单突触抑制摄食命令神经元PC， PSE和其他主要中间神经元I2s。这种机制对适合逃避反应的取食网络施加广泛的抑制；在习得性和饱足性食物回避中，比进食抑制更广泛，并通过不同的突触前通路起作用。游泳网络的四个内在神经调节神经元，血清素能As1-4，对直接抑制摄食作用不大。相反，它们单突触地激发进食网络中的5 -羟色胺能脑巨（MCG）神经元，这些神经元本身是进食的内在神经调节剂，以及邻近的一组5 -羟色胺能进食神经元，具有快速和缓慢的epsp。它们还为PC、IPSE喂养指令神经元以及I1和I2喂养中间神经元提供轻度的神经调节兴奋，这些兴奋在游泳过程中被抑制所掩盖。As1-4也能刺激5 -羟色胺能足神经节G神经元进行爬行运动。这些观察结果进一步描述了腹足类动物的血清素能唤醒系统的性质，并提出了As1-4的中心协调作用。
Escape swimming in the predatory sea slug Pleurobranchaea. is a dominant behavior that overrides feeding, a behavioral switch caused by swim-induced inhibition of feeding command neurons. We have now found distinct roles for the different swim interneurons in acute suppression of feeding during the swim and in a longer-term stimulation of excitability in the feeding network. The identified pattern-generating swim neurons Al, A3, A10, and their follower interneuron A-ci1, suppress feeding motor output partly by excitation of the I1 feeding interneurons, which monosynaptically inhibit both the feeding command neurons, PC,, PSE, and other major interneurons, the I2s. This mechanism exerts broad inhibition of the feeding network suitable to an escape response; broader than feeding suppression in learned and satiation-induced food avoidance and acting through a different presynaptic pathway. Four intrinsic neuromodulatory neurons of the swim network, the serotonergic As1-4, add little to direct suppression of feeding. Rather, they monosynaptically excite the serotonergic metacerebral giant (MCG) neurons of the feeding network, themselves intrinsic neuromodulators of feeding, as well as a cluster of adjacent serotonergic feeding neurons, with both fast and slow EPSPs. They also provide mild neuromodulatory excitation of the PC,IPSE feeding command neurons, and I1 and I2 feeding interneurons, which is masked by inhibition during the swim. As1-4 also excite the serotonergic pedal ganglion G neurons for creeping locomotion. These observations further delineate the nature of the putative serotonergic arousal system of gastropods and suggest a central coordinating role to As1-4.