Implementing Logic Gates by DNA Crystal Engineering
Implementing Logic Gates by DNA Crystal Engineering
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DOI：
10.1002/adma.202302345
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发表时间：
2023-07-10
影响因子：
29.4
通讯作者：
Mao，Chengde
中科院分区：
文献类型：
--
作者：
Zhang，Cuizheng;Paluzzi，Victoria E.;Mao，Chengde
DNA自组装计算是有吸引力的，因为它有可能在分子水平上进行大规模并行信息处理，同时保持其天然的生物相容性。它已经在单个分子水平上进行了广泛的研究，但没有3D中的合奏那么多。在这里，实现逻辑门的可行性，基本的计算操作，在大型合奏：宏观，工程3D DNA晶体被证明。构建模块是最近开发的DNA双交叉样（DXL）基序。它们可以通过粘端凝聚力相互联系。公共逻辑门是通过对基元的粘性末端内的输入进行编码来实现的。通过形成可以容易地观察到的宏观晶体来证明输出。这项研究指出了构建复杂的3D晶体结构和基于DNA的生物传感器的新方向。
DNA self‐assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals is demonstrated. The building blocks are the recently developed DNA double crossover‐like (DXL) motifs. They can associate with each other via sticky‐end cohesion. Common logic gates are realized by encoding the inputs within the sticky ends of the motifs. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA‐based biosensors with easy readouts.