Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study.
Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study.
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DOI：
10.3233/jad-2009-1163
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Burns JM
中科院分区：
文献类型：
--
作者：
Honea RA;Vidoni E;Harsha A;Burns JM
载脂蛋白E（APOEε4）的神经影像学研究表明其与阿尔茨海默病的脑萎缩有关。迄今为止，很少有研究使用自动形态学分析技术来评估非痴呆老年人灰质和白色物质中APOEε4相关的脑结构变化。60岁以上的非痴呆（CDR = 0，n = 53）受试者进行了MRI、弥散张量成像和神经认知评估。我们使用基于体素的形态测量技术和基于轨迹的各向异性分数变化的空间统计，评估了与APOEε4遗传变异相关的认知和脑结构差异。与APOEε4阴性参与者相比，ε4等位基因的非痴呆老年人的认知能力降低，海马和杏仁核萎缩。我们还报道了ε4携带者在左侧海马旁回白色物质中的各向异性分数降低。总之，APOEε4等位基因在非痴呆老年人中的存在与认知能力下降以及内侧颞叶皮质的灰质和白色物质改变有关。总的来说，我们提供了进一步的证据，遗传变异的影响有关的成像和认知措施的风险阿尔茨海默氏病。
Neuroimaging studies of apolipoprotein E (APOEε4) have implicated its association with brain atrophy in Alzheimer’s disease. To date, few studies have used automated morphological analysis techniques to assess APOEε4-related brain structure change in both gray and white matter in nondemented older adults. Nondemented (CDR = 0, n = 53) subjects over 60 had MRI, diffusion tensor imaging, and neurocognitive assessments. We assessed differences in cognition and brain structure associated with APOEε4 genetic variation using voxel-based morphometry techniques, and tract-based spatial statistics of fractional anisotropy change. In nondemented older adults with the ε4 allele, cognitive performance was reduced, and atrophy was present in the hippocampus and amygdala compared to APOEε4 negative participants. We also report that ε4 carriers have decreased fractional anisotropy in the left parahippocampal gyrus white matter. In conclusion, the presence of an APOEε4 allele in nondemented older adults is associated with decreases in cognition and gray and white matter changes in the medial temporal cortex. Overall we provide further evidence of the effects of genetic variance related to imaging and cognitive measures of risk for Alzheimer’s disease.