A behavioral paradigm for measuring perceptual distances in mice.
A behavioral paradigm for measuring perceptual distances in mice.
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DOI：
10.1016/j.crmeth.2022.100233
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发表时间：
2022-06-20
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特定刺激和相同通道的其他刺激之间的知觉相似性提供了关于感觉空间的结构和几何形状的宝贵信息。虽然通常在人类行为实验中进行评估，但其他物种的知觉相似性--或距离--很少被测量到。然而，理解负责感觉表征的神经计算需要监控并经常操纵神经活动，这在非人类实验模型中更容易实现。在这里，我们开发了一种行为范式，它能够使用小鼠嗅觉作为模型系统来量化感觉刺激之间的知觉相似性。老鼠可以学习指示任何两种气味刺激之间的知觉距离这一行为范式能够高通量量化感知距离这组气味之间的知觉关系在个体之间保持映射动物模型中的知觉空间可以解锁气味的神经代码理解感觉信息处理的基本原理需要良好的知觉空间结构和几何知识以及将刺激放置在该空间的相应地图上的能力。测量动物多对刺激之间的知觉距离使我们能够揭示知觉空间结构，从而允许未来对神经活动的测量和操纵来揭示负责塑造这个空间的神经机制。Nakayama等人。开发一种行为范式来确定老鼠体内气味刺激之间的知觉距离。这些距离形成了一个公制空间，将气味刺激与气味感知联系起来。这种方法可以与生理实验相结合，破解哺乳动物嗅觉的神经密码。
Perceptual similarities between a specific stimulus and other stimuli of the same modality provide valuable information about the structure and geometry of sensory spaces. While typically assessed in human behavioral experiments, perceptual similarities—or distances—are rarely measured in other species. However, understanding the neural computations responsible for sensory representations requires the monitoring and often manipulation of neural activity, which is more readily achieved in non-human experimental models. Here, we develop a behavioral paradigm that enables the quantification of perceptual similarity between sensory stimuli using mouse olfaction as a model system. Mice can learn to indicate the perceptual distance between any two odor stimuli This behavioral paradigm enables high-throughput quantification of perceptual distances Perceptual relationships between sets of odors are conserved across individuals Mapping perceptual space in an animal model can unlock the neural code for odors Understanding the basic principles of sensory information processing requires good knowledge of structure and geometry of perceptual spaces and the ability to place stimuli on a corresponding map of that space. Measuring perceptual distances between multiple pairs of stimuli in animals allows us to reveal the structure of the perceptual space, allowing future measurement and manipulation of neural activity to reveal the neural mechanisms responsible for shaping this space. Nakayama et al. develop a behavioral paradigm to determine perceptual distances between odorant stimuli in the mouse. These distances form a metric space linking odorant stimuli to odor perception. This method can be coupled with physiological experiments to crack the neural code for mammalian olfaction.