A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice
A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice
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DOI：
10.1006/hbeh.1997.1382
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发表时间：
1997-06-01
影响因子：
3.5
通讯作者：
Paylor, R
中科院分区：
文献类型：
--
作者：
Crawley, JN;Paylor, R
转基因和基因敲除小鼠的行为表型分析需要严格的正式分析。可以从已建立的行为神经科学文献中选择充分表征的范例。本文综述了（1）一系列神经学和神经心理学测试，这些测试有效地用作突变小鼠行为异常的第一筛选，以及（2）一系列特定的行为范式，按类别聚类。包括每个类别的多个范例，包括学习和记忆，喂养，镇痛，攻击，焦虑，抑郁，精神分裂症和药物滥用模型。从作者的经验，在应用这些实验设计转基因和基因敲除小鼠的例子。每一个行为范式提供了广泛的参考，让新的研究人员访问行为方法学的相关文献。
Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.