Inflammation in AIDS and the role of the macrophage in brain pathology
Inflammation in AIDS and the role of the macrophage in brain pathology
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DOI：
10.1097/00019052-199606000-00013
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发表时间：
1996-06-01
影响因子：
4.8
通讯作者：
Wiley, CA
中科院分区：
文献类型：
--
作者：
Achim, CL;Wiley, CA
HIV相关性痴呆症是艾滋病最严重的神经系统并发症。这种复杂的病理基础被称为HIV脑炎，其特点是大量感染和激活脑巨噬细胞。HIV脑炎的神经损害的发病机制基本上是未知的。目前的研究大多集中在潜在的病毒或巨噬细胞神经毒素上。
HIV-associated dementia complex is the most severe neurologic complication of AIDS. The pathologic substrate of the complex, termed HIV encephalitis, is marked by abundant infection and activation of brain macrophages. The pathogenesis of neurologic damage in HIV encephalitis is essentially undefined. Most current investigations are focused on potential viral or macrophage neurotoxins.