Serum adiponectin levels and lifestyle factors in Japanese men
Serum adiponectin levels and lifestyle factors in Japanese men
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DOI：
10.1007/s00380-006-0969-2
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发表时间：
2007-09-01
影响因子：
1.5
通讯作者：
Kurozawa, Yosuke Kato Youichi
中科院分区：
文献类型：
--
作者：
Kotani, Kazuhiko;Sakane, Naoki;Kurozawa, Yosuke Kato Youichi
脂联素在各种生活方式相关疾病的发展中起重要作用，如肥胖、高血压、II型糖尿病、高脂血症和代谢综合征，导致心脏和血管疾病的发展。然而，影响循环脂联素水平的决定因素，包括生活方式因素，仍然没有得到彻底的研究，特别是在一般男性人群中。共入组了109例生活方式稳定的健康日本男性受试者（平均年龄55 ± 14岁）。所有人都没有服药。采用酶联免疫吸附试验测定空腹血清脂联素水平。通过自我管理的Breslow问卷（一种评估各种生活方式的成熟方法）对每个受试者的生活方式进行了评估，并进行了微小的修改。偏相关分析显示，在控制年龄和生活方式因素后，血清脂联素水平与体重指数（BMI）呈显著的独立负相关（r =-0.222，P = 0.025），与睡眠时间呈显著的独立正相关（r = 0.252，P = 0.011）。脂联素与其他生活方式因素之间无显著相关性。这些数据表明，BMI增加和睡眠时间缩短可能是健康男性血清脂联素水平降低的重要独立风险。因此，这些因素可能是干预目标，调节脂联素到其适当的水平，以预防心血管疾病。
Adiponectin plays an important role in the development of various lifestyle-related diseases such as obesity, hypertension, type II diabetes mellitus, hyperlipidemia, and metabolic syndrome, leading to the development of heart and vascular diseases. However, the determinants that affect circulating adiponectin levels, including lifestyle factors, have still not been thoroughly investigated, in a general male population in particular. A total of 109 healthy Japanese male subjects (mean age, 55 +/- 14 years) with constant lifestyles were enrolled. All were on no medication. Fasting serum adiponectin levels were measured with an enzyme-linked immunosorbent assay. Each subject's lifestyle was assessed by the self-administered Breslow Questionnaire (a well-established method to estimate various lifestyles) with minor modifications. Partial correlation analysis for serum adiponectin levels, after controlling age and all lifestyle factors, revealed a significant and independent negative correlation between serum adiponectin levels and body mass index (BMI) (r = -0.222, P = 0.025), and a significant and independent positive correlation between serum adiponectin levels and sleep duration (r = 0.252, P = 0.011). No significant correlations were observed between adiponectin and other lifestyle factors. These data suggest that increased BMI and shorter sleep duration may be significant independent risks for low serum adiponectin levels in healthy males. Therefore, these factors may be intervention targets to modulate adiponectin to its proper levels for the prevention of cardiovascular disorders.