Changes in oscillatory cortical activity related to a visuomotor task in young and elderly healthy subjects
Changes in oscillatory cortical activity related to a visuomotor task in young and elderly healthy subjects
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DOI：
10.1016/s1388-2457(03)00058-0
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发表时间：
2003-06-01
影响因子：
4.7
通讯作者：
Derambure, P
中科院分区：
文献类型：
--
作者：
Labyt, E;Szurhaj, W;Derambure, P
目的：为了更好地了解视觉引导运动时激活的皮质区域的时空相互作用，并评估年龄对皮层活动时空格局的影响，我们比较了视觉-运动控制和手眼协调(靶向运动)的近远端运动与远端和近端运动。方法：采用皮层MU和β节律的事件相关去同步分析(ERD/S)来研究17名受试者的脑电活动。8名年轻人和9名老年人。结果：在两个人群中。在靶向运动的准备过程中，我们发现与远端和近端的运动相比，主要涉及对侧顶区的靶向运动有更早和更广泛的Mu和βERD。在执行过程中，观察到在近端运动期间在顶中心区和在靶向运动期间在顶区扩散。在执行近端和靶向运动后，仅在年轻受试者中观察到更宽和更高的βERS。在老年受试者中，我们的结果显示，在目标任务中，βERS显著减少。结论：这些结果表明，当运动被视觉引导时，皮质区域有更大的招募，尤其是顶叶皮质。此外，与大脑衰老相关的时空βERS模式的变化表明感觉统合受损。(C)2003年国际临床神经生理学联合会。爱思唯尔科学爱尔兰有限公司出版。版权所有。
Objective: In order to better understand the spatio-temporal interaction of the activated cortical areas when the movement is visuo-guided and to assess the age effect on the spatio-temporal pattern of cortical activity, we have compared a proximo-distal movement with visual-motor control and hand-eye coordination (targeting movement) with a distal and a proximal movement.Methods: Brain's electrical activity was studied using the analysis of event-related (de)synchronizations (ERD/S) of cortical mu and beta rhythms in 17 subjects. 8 young and 9 elderly subjects.Results: In both populations. we found an earlier and broader mu and beta ERD during the preparation of the targeting movement compared to distal and proximal movements, principally involving the contralateral parietal region. During the execution, a spreading over the parietocentral region during proximal movement and over the parietal region during targeting movement was observed. After the execution of proximal and targeting movements, a wider and higher beta ERS was observed only in the young subjects. In the elderly subjects, our results showed a significant decrease of beta ERS during the targeting task.Conclusions: These results suggest there was a larger recruitment of cortical areas, involving notably the parietal cortex when the movement is visuo-guided. Moreover, cerebral aging-related changes in the spatio-temporal beta ERS pattern suggests an impaired sensory integration. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.