Molecular targets of epigenetic regulation and effectors of environmental influences
Molecular targets of epigenetic regulation and effectors of environmental influences
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DOI：
10.1016/j.taap.2010.03.022
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发表时间：
2010-06-15
影响因子：
3.8
通讯作者：
Klaassen, Curtis D.
中科院分区：
文献类型：
--
作者：
Choudhuri, Supratim;Cui, Yue;Klaassen, Curtis D.
随着我们对DNA甲基化和染色质修饰及其对基因表达影响的了解的增加，我们对表观遗传学的真正理解也随着时间的推移而发展。目前表观遗传学研究的爆炸式增长以及各种环境因素对DNA甲基化、染色质修饰以及对小非编码RNA（ncRNA）表达的影响的越来越多的文献已经扩大了对包括癌症在内的各种疾病的病因学的研究范围。目前的审查简要讨论了表观遗传调控的分子机制，并扩大了讨论与环境的作用，如在发展过程中的直接环境，在诱导表观遗传变化和调节基因表达的例子。爱思唯尔公司出版
The true understanding of what we currently define as epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression increased. The current explosion of research on epigenetics and the increasing documentation of the effects of various environmental factors on DNA methylation, chromatin modification, as well as on the expression of small non-coding RNAs (ncRNAs) have expanded the scope of research on the etiology of various diseases including cancer. The current review briefly discusses the molecular mechanisms of epigenetic regulation and expands the discussion with examples on the role of environment, such as the immediate environment during development, in inducing epigenetic changes and modulating gene expression. Published by Elsevier Inc.