SERS-Encoded Nanogapped Plasmonic Nanoparticles: Growth of Metallic Nanoshell by Templating Redox-Active Polymer Brushes
SERS-Encoded Nanogapped Plasmonic Nanoparticles: Growth of Metallic Nanoshell by Templating Redox-Active Polymer Brushes
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DOI：
10.1021/ja502024d
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发表时间：
2014-05-14
影响因子：
15
通讯作者：
Duan, Hongwei
中科院分区：
文献类型：
--
作者：
Song, Jibin;Duan, Bo;Duan, Hongwei
我们报道了一种新的策略，通过两亲嵌段共聚物的纳米颗粒模板自组装和氧化还原活性聚合物刷的局部金属前体还原，合成具有内部拉曼标签编码的纳米间隙的核-壳金属纳米颗粒。表面增强拉曼散射(SERS)特别令人感兴趣的是，纳米间隙的大小可以灵活地定制，小于2 nm的纳米间隙导致最大的表面增强拉曼散射增强。我们的结果进一步证明，带有适体靶向配体的纳米金纳米颗粒的表面功能化允许对癌细胞进行特定的识别和超灵敏的检测。这一新的合成策略的普遍适用性，再加上功能纳米晶体的受控湿化学合成的最新进展，为获得集光学、电子和磁性于一体的多功能核壳纳米粒子开辟了新的途径。
We report a new strategy to synthesize core-shell metal nanoparticles with an interior, Raman tag-encoded nanogap by taking advantage of nanoparticle-templated self-assembly of amphiphilic block copolymers and localized metal precursor reduction by redox-active polymer brushes. Of particular interest for surface-enhanced Raman scattering (SERS) is that the nanogap size can be tailored flexibly, with the sub-2 nm nanogap leading to the highest SERS enhancement. Our results have further demonstrated that surface functionalization of the nanogapped Au nanoparticles with aptamer targeting ligands allows for specific recognition and ultrasensitive detection of cancer cells. The general applicability of this new synthetic strategy, coupled with recent advances in controlled wet-chemical synthesis of functional nanocrystals, opens new avenues to multifunctional core-shell nanoparticles with integrated optical, electronic, and magnetic properties.