The effects of loading and estrogen on rat bone growth
The effects of loading and estrogen on rat bone growth
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DOI：
10.1152/japplphysiol.00989.2009
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Jarvinen, Teppo L. N.
中科院分区：
文献类型：
--
作者：
Leppanen, Olli V.;Sievanen, Harri;Jarvinen, Teppo L. N.
Leppanen OV，Sievanen H，Jokihaara J，Pajamaki I，Kannus P，库珀DM，Jarvinen TL.负荷和雌激素对大鼠骨生长的影响。J Appl Physiol 108：1737-1744，2010.首次出版于2010年4月8日; doi：10.1152/japplphysiol. 00989.2009.-本研究探讨了运动负荷和雌激素对大鼠股骨干发育的影响。采用随机2 × 2研究设计。总共使用了70只雌性Sprague-Dawley大鼠，其中10只在入组时人道处死。在剩下的大鼠中，16只作为对照，其余44只接受单侧坐骨神经切除术。雌激素的影响被删除卵巢切除一半的神经切除大鼠。27周后，将动物安乐死，并切除股骨。不考虑负荷或雌激素，股骨长度和矿物质质量分别增加了142%和687%。轴向生长没有调制无论是机车负荷或雌激素，但负荷导致的方向特定的变化，在横截面的几何形状。雌激素相关的增益是明显的皮质内表面，而负载相关的增益发生在骨膜表面。载荷和雌激素与中外侧方向的骨强度增加显著相关（分别为21%和15%），但与前后方向无关。轴向生长和增量的大鼠股骨的骨矿物质的质量在很大程度上是独立的运动负荷或雌激素，而这些因素具体占股骨功能，无论是机械杠杆或矿物水库繁殖，分别。
Leppanen OV, Sievanen H, Jokihaara J, Pajamaki I, Kannus P, Cooper DM, Jarvinen TL. The effects of loading and estrogen on rat bone growth. J Appl Physiol 108: 1737-1744, 2010. First published April 8, 2010; doi:10.1152/japplphysiol. 00989.2009.-This study evaluated the contributions of locomotive loading and estrogen to the development of diaphysis of rat femur. A randomized 2 X 2 study design was used. Altogether, 70 female Sprague-Dawley rats were used, of which 10 were euthanized at entry. Of the remaining rats, 16 served as controls, and the rest, 44, underwent a unilateral sciatic neurectomy. The effect of estrogen was removed by ovariectomizing one-half of the neurectomized rats. After 27 wk, the animals were euthanized, and the femora were excised. Irrespective of loading or estrogen, the femur length and mineral mass increased by 142 and 687%, respectively. Axial growth was not modulated either by locomotive loading or estrogen, but the loading resulted in direction-specific changes in the cross-sectional geometry. The estrogen-related gains were evident on the endocortical surface, while the loading-related gains occurred on the periosteal surface. The loading and estrogen were significantly associated with increased bone strength (21 and 15%, respectively) in the mediolateral direction, but not in the anteroposterior direction. Axial growth and accrual of bone mineral mass of the rat femur are largely independent of locomotive loading or estrogen, whereas these factors specifically account for the femur function, as either a mechanical lever or a mineral reservoir for reproduction, respectively.