The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
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来自全基因组关联研究的 PSCA 多态性与胃癌风险相关：荟萃分析
DOI：
10.1007/s00432-012-1210-6
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发表时间：
2012-08-01
影响因子：
3.6
通讯作者：
Zhang, Zhengdong
中科院分区：
文献类型：
--
作者：
Shi, Danni;Wang, Shizhi;Zhang, Zhengdong
前列腺干细胞抗原 (PSCA) 是一种糖基磷脂酰肌醇锚定的 123-aa 蛋白，与细胞增殖抑制和/或细胞死亡诱导活性相关。许多研究报道了 PSCA rs2294008 C > T 和 rs2976392 G > A 多态性对胃癌风险的作用。为了更精确地估计这些关系，我们对 9 项病例对照研究（包括 10,746 例病例和 9,158 例对照）进行了荟萃分析。使用优势比 (OR) 和 95% 置信区间 (CI) 来评估关联强度。对于 PSCA rs2294008 C > T 多态性，所有遗传模型中胃癌的风险均显着增加（TT/TC 与 CC：OR = 1.61，95 % CI = 1.35-1.91；TT 与 TC/CC：OR = 1.33、95 % CI = 1.24-1.42）。 PSCA rs2976392 G > A 多态性也观察到类似结果（AA/AG 与 GG：OR = 1.69，95% CI = 1.24-2.31；AA 与 AG/GG：OR = 1.36，95% CI = 1.24-1.50）。在rs2294008的种族分层分析中，发现亚洲人（TT vs. TC/CC：OR = 1.31，95% CI = 1.22-1.42）和欧洲人（TT/TC vs. CC：OR = 1.42，95% CI = 1.18-1.71）胃癌风险增加。此外，根据肿瘤位置和组织学的临床病理特征进行分层时，与贲门型胃癌相比，非贲门型胃癌的风险更高（TT vs. TC/CC：OR = 1.43，95 % CI = 1.12-1.83），与弥漫性胃癌相比（TT vs. TC/CC：OR = 1.29，95 % CI = 1.13-1.49）风险更高。这些发现支持PSCA rs2294008 C > T和rs2976392 G > A多态性可能导致胃癌易感性，特别是在非贲门癌或弥漫性胃癌中。
Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.To investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case-control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.For PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35-1.91; TT vs. TC/CC: OR = 1.33, 95 % CI = 1.24-1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24-2.31; AA vs. AG/GG: OR = 1.36, 95 % CI = 1.24-1.50). In the stratified analysis by ethnicity of rs2294008, an increased gastric cancer risk was found in both Asians (TT vs. TC/CC: OR = 1.31, 95 % CI = 1.22-1.42) and Europeans (TT/TC vs. CC: OR = 1.42, 95 % CI = 1.18-1.71). Furthermore, when stratified by clinicopathologic characteristics of tumor location and histology, a higher risk on non-cardia compared with cardia gastric cancer (TT vs. TC/CC: OR = 1.43, 95 % CI = 1.12-1.83) as same as diffused compared with intestinal gastric cancer (TT vs. TC/CC: OR = 1.29, 95 % CI = 1.13-1.49) was observed.These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.