The dark side of activation-induced cytidine deaminase: Relationship with leukemia and beyond
The dark side of activation-induced cytidine deaminase: Relationship with leukemia and beyond
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DOI：
10.1532/ijh97.06011
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发表时间：
2006-04-01
影响因子：
2.1
通讯作者：
Nonaka, T
中科院分区：
文献类型：
--
作者：
Kinoshita, K;Nonaka, T
激活诱导的胞苷脱氨酶（AID）是一种独特的细胞酶，其可以触发点突变和染色体易位，这两者都可能干扰正常的细胞代谢并影响癌症的发生和进展。基于对AID表达与B细胞慢性淋巴细胞白血病不良预后之间的统计学相关性的观察，多个研究小组已经提出AID参与白血病的进展。AID在小鼠中的异位表达导致肺和T淋巴细胞肿瘤的事实表明AID的致癌作用。AID表达的可诱导性质表明AID可能被诱导并引起致癌突变，甚至在正常条件下AID表达不存在或非常弱的上皮组织中也是如此。如果AID可以在上皮细胞中由炎性信号诱导，如来自B淋巴细胞，则它可能涉及各种病理状况，包括炎症和感染相关的癌症，尽管这些疾病具有临床意义，但其分子机制在很大程度上是未知的。
Activation-induced cytidine deaminase (AID) is a unique cellular enzyme that can trigger point mutations and chromosomal translocations, both of which potentially disturb normal cellular metabolism and affect cancer initiation and progression. The involvement of AID in the progression of leukemia has been suggested by multiple groups on the basis of observations of the statistical correlation between AID expression and a poor prognosis of B-cell chronic lymphocytic leukemia. The fact that ectopic expression of AID in mice results in tumors of the lung and T-lymphocytes suggests an oncogenic role for AID. The inducible nature of AID expression indicates that AID might be induced and cause oncogenic mutations, even in epithelial tissues, where AID expression is absent or very weak under normal conditions. If AID can be induced in epithelial cells by inflammatory signals, as from B-lymphocytes, it may be involved in various pathologic conditions, including inflammation- and infection-associated cancers, for which the molecular mechanism is largely unknown, despite the clinical significance of these diseases.