Human Polyomavirus 7-Associated Pruritic Rash and Viremia in Transplant Recipients
Human Polyomavirus 7-Associated Pruritic Rash and Viremia in Transplant Recipients
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DOI：
10.1093/infdis/jiu524
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发表时间：
2015-05-15
影响因子：
6.4
通讯作者：
Chang, Yuan
中科院分区：
文献类型：
--
作者：
Ho, Jonhan;Jedrych, Jaroslaw J.;Chang, Yuan
人类多瘤病毒7（HPyV 7）是最近通过基因组测序技术发现的11种HPyV之一。两名接受免疫抑制治疗的肺移植受者在躯干和四肢上出现皮炎，棕色斑块，显示出独特的表皮增生，含有密集的36-45 nm二十面体衣壳的病毒负载角质形成细胞。滚环扩增和梯度离心检测均为阳性，从两名患者的皮肤和外周血标本中的HPyV 7 DNA，HPyV 7早期和衣壳蛋白在受影响的组织中大量表达。我们首次描述了HPyV 7与某些免疫抑制个体的新型致病性相关。
Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.