METASTATIC PATTERNS IN OSTEO-SARCOMA
METASTATIC PATTERNS IN OSTEO-SARCOMA
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DOI：
10.1177/030089168807400408
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发表时间：
1988-08-31
期刊：
影响因子：
1.9
通讯作者：
CAMPANACCI, M
中科院分区：
文献类型：
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作者：
BACCI, G;AVELLA, M;CAMPANACCI, M
我们回顾了193例高级别非转移性骨肉瘤患者的临床病程，以确定疾病自然史的演变。所有患者的原发病灶均位于四肢，并于1976年至1982年在Rizzoli骨科研究所接受了单独手术（30例）或手术加辅助化疗（163例）治疗。所有患者在我们研究所定期随访。114例患者，其中27例仅接受手术治疗，87例接受辅助化疗，发生明显的转移性疾病。两组中首次复发的部位（约90%的病例为肺部）无差异。然而，在接受辅助化疗的患者组中，与非辅助化疗患者相比，明显转移性疾病的发展随时间延迟（13个月vs 8个月），首次复发时肺部转移性结节的数量减少。由于辅助化疗导致的转移模式的这种改变是重要的，因为它允许在大量患者中手术切除肺转移瘤（51%对29%）。
The clinical courses of 193 patients with high-grade, non-metastatic osteosarcoma were reviewed to ascertain the evolution of the natural history of the disease. All patients had the primary lesion in the extremities and were treated at the Rizzoli Orthopaedic Institute between 1976 and 1982 with surgery alone (30 cases) or surgery plus adjuvant chemotherapy (163 cases). All patients were regularly followed at our Institute. One hundred and fourteen patients, of which 27 were treated with surgery alone and 87 treated with adjuvant chemotherapy, developed overt metastatic disease. No differences were found concerning the sites of the first relapse which, for approximately 90% of cases, were lungs in both groups. However, in the group of patients treated with adjuvant chemotherapy the development of overt metastatic disease, as compared to non-adjuvant patients, was delayed with time (13 vs 8 months) and the number of metastatic nodules in the lung at first relapse was reduced. This alteration in metastatic pattern due to adjuvant chemotherapy is important because it allows surgical resection of pulmonary metastases in a large number of patients (51% vs 29%).