ROLE OF OXYGEN RADICALS IN TOURNIQUET-RELATED ISCHEMIA-REPERFUSION INJURY OF HUMAN PATIENTS
ROLE OF OXYGEN RADICALS IN TOURNIQUET-RELATED ISCHEMIA-REPERFUSION INJURY OF HUMAN PATIENTS
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DOI：
10.1007/bf01645168
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发表时间：
1991-12-15
期刊：
影响因子：
--
通讯作者：
WARD, PA
中科院分区：
文献类型：
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作者：
FRIEDL, HP;TILL, GO;WARD, PA
在目前的研究中，我们评估了接受重建手术治疗的人类患者四肢流出的血液，重建手术通常伴随着上肢出血和止血带的应用。止血带松开(再灌流)后，血浆中黄嘌呤氧化酶活性、尿酸和组胺水平立即升高。未检测到黄嘌呤脱氢酶活性。血浆中还含有与氧自由基形成相一致的产物，即血红蛋白和荧光化合物。我们的数据表明，在人类中，缺血-再灌注事件与血浆流出物中黄嘌呤氧化酶活性及其产物的出现有关。
In the current study we evaluated effluent blood from extremities of human patients undergoing reconstructive surgical treatment which is routinely accompanied by upper extremity exsanguination and application of a tourniquet. Following tourniquet release (reperfusion), there were immediate increases in the plasma levels of xanthine oxidase activity, uric acid, and histamine. Xanthine dehydrogenase activity was not detectable. Plasma also contained products consistent with the formation of oxygen-derived free radicals, namely hemoglobin and fluorescent compounds. Our data indicate in humans that ischemia-reperfusion events are associated with the appearance of xanthine oxidase activity and it's products in the plasma effluent.