[Estimating the disease burden of seasonal influenza in China, 2006-2019].
[Estimating the disease burden of seasonal influenza in China, 2006-2019].
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DOI：
10.3760/cma.j.cn112137-20201210-03323
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发表时间：
2021-03-02
影响因子：
--
通讯作者：
Yu, H J
中科院分区：
文献类型：
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作者：
Gong, H;Shen, X;Yu, H J
目的：评估中国大陆季节性流感的健康影响和经济负担。研究方法：通过系统性文献综述，我们收集了2006-2017年流感相关的过度流感样疾病（ILI）门诊就诊率、严重急性呼吸道感染（SARI）住院率和呼吸道过度死亡率。使用这些数据以及人口统计学数据（2019年），估计了流感相关的ILI过度门诊咨询、SARI住院和呼吸道过度死亡的数量。然后使用流感相关门诊和住院的人均经济负担，以及流感相关过早死亡的生产力损失，估计每年流感相关的总经济负担。所有成本均使用消费者价格指数调整至2019年。结果如下：每年流感相关的ILI门诊、SARI住院和呼吸道死亡分别为300万、234万和09万。总经济负担263.8亿CNY，占2019年GDP的0.266，其中住院相关经济负担占比最高（86.4%，227.9亿CNY），其次是门诊相关经济负担（11.3%，29.7亿CNY），过早死亡的生产力损失间接经济负担最低（2.4%，6.2亿CNY）。经济负担最大的是华东地区（105.1亿CNY），最小的是东北地区（3.8亿CNY）。结论：流感相关门诊就诊和住院的健康负担是巨大的。流感相关SARI住院的经济负担高于流感相关门诊患者和过早死亡。华东地区流感经济负担最高。
Objective: To estimate the health impact and economic burden of seasonal influenza in mainland China. Methods: From systematic literature reviews, we collected the influenza-associated excess influenza-like-illness (ILI) outpatient consultation rates, hospitalization rates of severe acute respiratory infections (SARI) and respiratory excess mortality, 2006-2017. Using these data, as well as demographic data (2019), the number of influenza-associated excess ILI outpatient consultations, SARI hospitalizations and respiratory excess deaths were estimated. Then using per capita economic burden of influenza-associated outpatient consultations and hospitalizations, as well as the productivity loss of influenza-related premature deaths, the annual influenza-associated total economic burden was estimated. All costs were adjusted to 2019 using the consumer price index. Results: The annual influenza-associated excess ILI outpatient consultations, SARI hospitalizations and excess respiratory deaths were 3 million, 2.34 million, 0.09 million, respectively. The total economic burden was 26.38 billion CNY, accounting for 0.266 GDP in 2019, of which the hospitalization-related economic burden accounted for the highest proportion (86.4%, 22.79 billion CNY), followed by the outpatient-related economic burden (11.3%, 2.97 billion CNY), and the indirect economic burden of productivity loss of premature deaths was the lowest (2.4%, 0.62 billion CNY). Largest economic burden was observed in East China (10.51 billion CNY) and smallest observed in Northeast China (0.38 billion CNY). Conclusion: The health burden of influenza-related outpatient visits and hospitalizations were substantial. The economic burden of influenza-related SARI hospitalization was higher than that of influenza-related outpatients and pre-mature deaths. The highest economic burden of influenza occurred in the East China.