Overexpression of YAP1 is Correlated with Progression, Metastasis and Poor Prognosis in Patients with Gastric Carcinoma
Overexpression of YAP1 is Correlated with Progression, Metastasis and Poor Prognosis in Patients with Gastric Carcinoma
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DOI：
10.1007/s12253-014-9757-y
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发表时间：
2014-10-01
影响因子：
2.8
通讯作者：
Zhao, Jing
中科院分区：
文献类型：
--
作者：
Hu, Xiaobin;Xin, Yan;Zhao, Jing
YAP 1在多种肿瘤中过表达，但其在肿瘤发生中的分子机制以及在肿瘤诊断和预后中的临床意义尚不明确。本研究旨在分析YAP 1表达的临床病理意义及其与胃癌进展、转移和预后的关系。应用免疫组织化学方法检测214例原发性胃癌、167例正常胃粘膜、40例慢性萎缩性胃炎、11例异型增生和73例肠上皮化生中YAP 1的表达。YAP 1在胃癌组织中的阳性表达率显著高于正常胃粘膜、慢性萎缩性胃炎和肠上皮化生组织。在有淋巴结转移的胃癌中，YAP 1的阳性率明显高于无淋巴结转移的胃癌。此外，YAP 1过表达的胃癌患者的预后比YAP 1阴性表达的患者差。多因素分析显示，YAP 1过表达、浸润深度和淋巴结转移是胃癌发生的高危因素。结果表明，YAP 1的过表达与胃癌的进展、淋巴结转移和预后不良有关，提示YAP 1的过表达可能是预测胃癌淋巴结转移的辅助因子，也可能是胃癌诊断和预后判断的有用生物标志物。
YAP1 is overexpressed in numerous cancers, but its molecular mechanism in the carcinogenesis and clinic significance in tumor diagnosis and prognosis remains to be determined. We attempted to analyze the clinicopathologic significance of YAP1 expression and the correlation of the YAP1 levels with the progression, metastasis and prognosis of patients with gastric carcinoma. By immunohistochemistry, we determined YAP1 expression in 214 of primary gastric carcinoma (GC), 167 of matched normal gastric mucosa, 40 of chronic atrophic gastritis, 11 of dysplasia and 73 of intestinal metaplasia. The positive rate of YAP1 in gastric carcinoma was significantly higher than that in normal gastric mucosa, chronic atrophic gastritis and intestinal metaplasia. In the gastric cancers with lymph node metastasis, the positive rate of YAP1 was much higher than that in the group without lymph node metastasis. Moreover, gastric cancer patients with YAP1 overexpression demonstrated poorer prognosis than those with YAP1 negative staining. Finally, multivariate analysis of 191 patients with gastric carcinoma indicated that YAP1 overexpression, the invasion depth and lymph node metastasis were high hazard factors for gastric carcinoma. Our results demonstrated that YAP1 overexpression is correlated to the progression, lymph node metastasis and poor prognosis of gastric carcinoma, suggesting that overexpression of YAP1 might be an adjuvant factor for predicting lymph node metastasis, and a useful biomarker for the diagnosis and prediction of prognosis in patients with gastric cancers.