CDNA SEQUENCE AND CHROMOSOMAL LOCALIZATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR A-CHAIN AND ITS EXPRESSION IN TUMOR-CELL LINES
CDNA SEQUENCE AND CHROMOSOMAL LOCALIZATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR A-CHAIN AND ITS EXPRESSION IN TUMOR-CELL LINES
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DOI：
10.1038/320695a0
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发表时间：
1986-04-24
期刊：
影响因子：
64.8
通讯作者：
SCOTT, J
中科院分区：
文献类型：
--
作者：
BETSHOLTZ, C;JOHNSSON, A;SCOTT, J
人肿瘤细胞系衍生的血小板衍生生长因子（PDGF）A链的前体的氨基酸序列已经从互补DNA克隆和定位于7号染色体的基因推导出。该蛋白质显示出与PDGF B链前体的广泛同源性。在许多人类肿瘤细胞系中，血小板源生长因子A链基因的表达独立于血小板源生长因子B链的表达，相对分子质量为31，000的血小板源生长因子样生长因子的分泌与A链信使RNA的表达相关，但与B链信使RNA的表达无关。
The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.