Peptide antibiotics in action: investigation of polypeptide chains in insoluble environments by rotational-echo double resonance.
Peptide antibiotics in action: investigation of polypeptide chains in insoluble environments by rotational-echo double resonance.
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DOI：
10.1016/j.bbamem.2006.02.031
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发表时间：
2006-09
期刊：
影响因子：
--
通讯作者：
O. Tőke;L. Cegelski;J. Schaefer
中科院分区：
文献类型：
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作者：
O. Tőke;L. Cegelski;J. Schaefer
旋转回波双共振（REDOR）是一种固态NMR技术，能够在不可结晶、难溶的异质分子系统（如细胞膜和细胞壁）中提供分子内和分子间距离和取向限制。在这篇综述中，我们将提出两个应用的REDOR：调查的爪蟾抗菌肽相关的脂质双层和研究的万古霉素样糖肽的细胞壁中的金黄色葡萄球菌。
Rotational-echo double resonance (REDOR) is a solid-state NMR technique that has the capability of providing intra- and intermolecular distance and orientational restraints in non-crystallizable, poorly soluble heterogeneous molecular systems such as cell membranes and cell walls. In this review, we will present two applications of REDOR: the investigation of a magainin-related antimicrobial peptide in lipid bilayers and the study of a vancomycin-like glycopeptide in the cell walls of Staphylococcus aureus.