An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing
An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing
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DOI：
10.1039/c6ra01167e
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Ding, Zhongtao
中科院分区：
文献类型：
--
作者：
Lin, Na;Chen, Xiaohong;Ding, Zhongtao
研制了一种pH敏感的双发射荧光探针，该探针在碱性条件下去质子化后发出绿色荧光，在酸性条件下聚集态发出橙子荧光。该探针可在癌细胞和裸鼠肿瘤的酸性溶酶体中特异性发光，在肿瘤诊断中具有潜在的应用价值。
A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.