Patterns of human tumor-infiltrating lymphocytes in 120 human cancers.
Patterns of human tumor-infiltrating lymphocytes in 120 human cancers.
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DOI：
10.1001/archsurg.1990.01410140078012
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发表时间：
1990-02
影响因子：
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通讯作者：
C. Balch;Lee B. Riley;Yoon Joo Bae;M. Salmeron;C. Platsoucas;A. C. Eschenbach;K. Itoh
中科院分区：
文献类型：
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作者：
C. Balch;Lee B. Riley;Yoon Joo Bae;M. Salmeron;C. Platsoucas;A. C. Eschenbach;K. Itoh
我们对120例人类癌症（包括黑色素瘤、肾细胞癌、乳腺癌、肉瘤和结肠癌）的肿瘤浸润淋巴细胞进行了检测。淋巴细胞从癌症中恢复的百分比差异很大；肾细胞癌高于乳腺癌或结肠癌（65%比45%），高于黑色素瘤或肉瘤（30%比35%）。白细胞介素2激活前后淋巴细胞的类型表现出特定的模式。除黑色素瘤外，所有肿瘤均以CD4+辅助T细胞为主，而黑色素瘤中CD8+细胞毒性T细胞较多。CD16+自然杀伤细胞在肾细胞癌和肉瘤中均有恢复。在白细胞介素2激活的肿瘤浸润淋巴细胞中鉴定出三种不同的细胞毒性淋巴细胞：(1)CD3+ CD16-细胞毒性T淋巴细胞，其细胞毒性仅限于黑色素瘤中的自体肿瘤细胞；(2)CD3-CD16+自然杀伤细胞，具有强烈的主要组织相容性复合物-非限制性细胞毒性，用于肾细胞癌；(3)CD3+ CD16- T细胞，其主要组织相容性复合物水平中等-非限制性细胞毒性，用于除黑色素瘤外的所有癌症。因此，在这些组织学上不同的肿瘤中，肿瘤浸润淋巴细胞在淋巴细胞浸润程度、表型表达和功能能力方面存在相当大的多样性。
Tumor-infiltrating lymphocytes from 120 samples of human cancers, including melanoma, renal cell carcinoma, breast cancer, sarcoma, and colon cancer, were examined. The percentage of lymphocytes recovered from the cancer varied widely; that of renal cell carcinoma was higher than that of breast or colon cancer (65% vs 45%), which was higher than that of melanomas or sarcomas (30% to 35%). The types of lymphocytes before and after interleukin 2 activation showed specific patterns. CD4+ helper T cells predominated in all tumors except melanomas, which had more CD8+ cytotoxic T cells. CD16+ natural killer cells were recovered in renal cell carcinoma and sarcomas. Three different cytotoxic lymphocytes were identified among interleukin 2-activated tumor-infiltrating lymphocytes: (1) CD3+ CD16- cytotoxic T lymphocytes with cytotoxicity restricted to autologous tumor cells in melanomas, (2) CD3-CD16+ natural killer cells with vigorous major histocompatibility complex-nonrestricted cytotoxicity in renal cell carcinoma, and (3) CD3+ CD16- T cells with modest levels of major histocompatibility complex-nonstricted cytotoxicity in all cancers except melanomas. Thus, there was considerable diversity of tumor-infiltrating lymphocytes among these histologically distinct tumors with respect to magnitude of lymphocyte infiltration, phenotypic expression, and functional capacity.