Epigenetic aging of the demographically non-aging naked mole-rat.
Epigenetic aging of the demographically non-aging naked mole-rat.
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DOI：
10.1038/s41467-022-27959-9
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发表时间：
2022-01-17
影响因子：
16.6
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Kerepesi C;Meer MV;Ablaeva J;Amoroso VG;Lee SG;Zhang B;Gerashchenko MV;Trapp A;Yim SH;Lu AT;Levine ME;Seluanov A;Horvath S;Park TJ;Gorbunova V;Gladyshev VN
裸鼹鼠（NMR）是一种寿命非常长的啮齿动物，其死亡率不会随年龄的增长而增加，将其定义为人口统计学上的非衰老哺乳动物。在这里，我们对> 100个NMR的血液进行亚硫酸氢盐测序，评估> 300万个常见CpG位点。基于甲基化与年龄相关的位点的无监督聚类揭示了与年龄相关的甲基化重塑，我们还观察到甲基化信息丢失，表明NMR年龄。我们开发了一个表观遗传衰老时钟，准确地预测NMR年龄。我们发现，这些动物的衰老速度比小鼠慢得多，比人类快得多，这与它们已知的最大寿命一致。有趣的是，Tert和Prpf19中时钟位点的年龄相关变化模式在NMR和小鼠之间不同，但也有两个物种之间保守的位点。总之，这些数据表明，NMR，像其他哺乳动物，表观遗传年龄，即使在没有人口老龄化的这个物种。裸鼹鼠寿命特别长，其特点是不随年龄增长而增加死亡率。在这里，作者进行了表观遗传学研究，表明裸鼹鼠的表观遗传年龄，尽管他们的死亡率没有增加。
The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the blood of > 100 NMRs, assessing > 3 million common CpG sites. Unsupervised clustering based on sites whose methylation correlates with age reveals an age-related methylome remodeling, and we also observe a methylome information loss, suggesting that NMRs age. We develop an epigenetic aging clock that accurately predicts the NMR age. We show that these animals age much slower than mice and much faster than humans, consistent with their known maximum lifespans. Interestingly, patterns of age-related changes of clock sites in Tert and Prpf19 differ between NMRs and mice, but there are also sites conserved between the two species. Together, the data indicate that NMRs, like other mammals, epigenetically age even in the absence of demographic aging of this species. The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.7
作者：
Benisch P;Schilling T;Klein-Hitpass L;Frey SP;Seefried L;Raaijmakers N;Krug M;Regensburger M;Zeck S;Schinke T;Amling M;Ebert R;Jakob F
通讯作者：
Jakob F
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S
影响因子：
2.5
作者：
Edrey, Yael H.;Hanes, Martha;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle